| Haemolytic uraemic syndrome: prognostic factors. | |
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MedLine Citation:
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PMID: 10762298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Haemolytic uraemic syndrome (HUS) associated with Escherichia coli O157:H7 is the commonest cause of acute renal failure (ARF) in childhood. Production of verotoxin by the organism is pivotal in the pathogenesis of the disease. Verotoxin binds to a receptor on blood and endothelial cells, expressed as the P1 blood group antigen on red blood cells. A protective effect of the P1 phenotype has been proposed in this disease. This study investigates prognostic factors and the relationship between outcome and P1 phenotype in 27 cases of diarrhoea-associated HUS. A poor outcome as defined by the presence of chronic renal failure (CRF), hypertension or proteinuria on 6 month follow-up was associated with the age of the patient at presentation and with the following clinical markers: maximum WBC and duration of raised WBC, duration of anuria and duration of need for dialysis. None of these outcome measures or prognostic factors, and no extra-renal manifestations of the disease were associated with P1 phenotype. |
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Authors:
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D A Green; W G Murphy; W S Uttley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and laboratory haematology Volume: 22 ISSN: 0141-9854 ISO Abbreviation: Clin Lab Haematol Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-05-18 Completed Date: 2000-05-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7907061 Medline TA: Clin Lab Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 11-4 Citation Subset: IM |
Affiliation:
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Royal Hospital for Sick Children, Royal Infirmary, Edinburgh, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Biological Markers Child Child, Preschool Diarrhea / microbiology Escherichia coli Infections / complications, epidemiology, immunology Escherichia coli O157 Female Hemolytic-Uremic Syndrome / complications*, epidemiology, microbiology Humans Hypertension / etiology, immunology Infant Kidney Failure, Acute / etiology, immunology, microbiology Male P Blood-Group System / genetics Phenotype Prognosis Proteinuria / etiology, immunology Risk Factors Scotland / epidemiology Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/P Blood-Group System |
| Comments/Corrections | |
Comment In:
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Clin Lab Haematol. 2000 Feb;22(1):55
[PMID:
10819611
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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