Document Detail


Haemolytic uraemic syndrome: prognostic factors.
MedLine Citation:
PMID:  10762298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Haemolytic uraemic syndrome (HUS) associated with Escherichia coli O157:H7 is the commonest cause of acute renal failure (ARF) in childhood. Production of verotoxin by the organism is pivotal in the pathogenesis of the disease. Verotoxin binds to a receptor on blood and endothelial cells, expressed as the P1 blood group antigen on red blood cells. A protective effect of the P1 phenotype has been proposed in this disease. This study investigates prognostic factors and the relationship between outcome and P1 phenotype in 27 cases of diarrhoea-associated HUS. A poor outcome as defined by the presence of chronic renal failure (CRF), hypertension or proteinuria on 6 month follow-up was associated with the age of the patient at presentation and with the following clinical markers: maximum WBC and duration of raised WBC, duration of anuria and duration of need for dialysis. None of these outcome measures or prognostic factors, and no extra-renal manifestations of the disease were associated with P1 phenotype.
Authors:
D A Green; W G Murphy; W S Uttley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  22     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-05-18     Completed Date:  2000-05-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Affiliation:
Royal Hospital for Sick Children, Royal Infirmary, Edinburgh, UK.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Biological Markers
Child
Child, Preschool
Diarrhea / microbiology
Escherichia coli Infections / complications,  epidemiology,  immunology
Escherichia coli O157
Female
Hemolytic-Uremic Syndrome / complications*,  epidemiology,  microbiology
Humans
Hypertension / etiology,  immunology
Infant
Kidney Failure, Acute / etiology,  immunology,  microbiology
Male
P Blood-Group System / genetics
Phenotype
Prognosis
Proteinuria / etiology,  immunology
Risk Factors
Scotland / epidemiology
Sex Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/P Blood-Group System
Comments/Corrections
Comment In:
Clin Lab Haematol. 2000 Feb;22(1):55   [PMID:  10819611 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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