| Haemolytic-uraemic syndrome in childhood: surveillance and case-control studies in Italy. Italian HUS Study Group. | |
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MedLine Citation:
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PMID: 7696109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seventy-six cases of haemolytic-uraemic syndrome (HUS) were collected over a 4-year period during a surveillance and case-control study. The annual incidence of 0.2 per 100,000 children aged 0-14 years is lower than in other countries; 34% had no prodromal diarrhoea. Evidence for verocytotoxin-producing Escherichia coli (VTEC) infection was found in 72% of patients and 3% of controls; 88% of patients with bloody diarrhoea, 67% with non-bloody diarrhoea and 55% without diarrhoea were VTEC positive. Seventy-three percent of patients had creatinine clearance > or = 80 ml/min per 1.73 m2, normal blood pressure, no proteinuria and haematuria < 2+ after 1 year of follow-up. One patient died and none had non-renal sequelae. VTEC positivity was significantly correlated with a good outcome, while the absence of diarrhoea and a high total white blood cell count at onset were not predictors of a bad outcome. Household contacts of HUS patients had diarrhoea more frequently than those of the control group, supporting the hypothesis of person-to-person transmission of VTEC infection. |
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Authors:
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A Gianviti; F Rosmini; A Caprioli; R Corona; M C Matteucci; F Principato; I Luzzi; G Rizzoni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 8 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-05-02 Completed Date: 1995-05-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 705-9 Citation Subset: IM |
Affiliation:
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Division of Nephrology and Dialysis, Bambino Gesù Children's Research Hospital, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bacterial Toxins / biosynthesis Case-Control Studies Child Child, Preschool Escherichia coli / metabolism Escherichia coli Infections / epidemiology*, microbiology Female Follow-Up Studies Hemolytic-Uremic Syndrome / epidemiology*, microbiology Humans Incidence Infant Infant, Newborn Italy / epidemiology Male Prognosis Questionnaires Retrospective Studies Risk Factors Shiga Toxin 1 |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; 0/Shiga Toxin 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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