Document Detail

Haemolytic-uraemic syndrome in childhood: surveillance and case-control studies in Italy. Italian HUS Study Group.
MedLine Citation:
PMID:  7696109     Owner:  NLM     Status:  MEDLINE    
Seventy-six cases of haemolytic-uraemic syndrome (HUS) were collected over a 4-year period during a surveillance and case-control study. The annual incidence of 0.2 per 100,000 children aged 0-14 years is lower than in other countries; 34% had no prodromal diarrhoea. Evidence for verocytotoxin-producing Escherichia coli (VTEC) infection was found in 72% of patients and 3% of controls; 88% of patients with bloody diarrhoea, 67% with non-bloody diarrhoea and 55% without diarrhoea were VTEC positive. Seventy-three percent of patients had creatinine clearance > or = 80 ml/min per 1.73 m2, normal blood pressure, no proteinuria and haematuria < 2+ after 1 year of follow-up. One patient died and none had non-renal sequelae. VTEC positivity was significantly correlated with a good outcome, while the absence of diarrhoea and a high total white blood cell count at onset were not predictors of a bad outcome. Household contacts of HUS patients had diarrhoea more frequently than those of the control group, supporting the hypothesis of person-to-person transmission of VTEC infection.
A Gianviti; F Rosmini; A Caprioli; R Corona; M C Matteucci; F Principato; I Luzzi; G Rizzoni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  8     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-02     Completed Date:  1995-05-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  705-9     Citation Subset:  IM    
Division of Nephrology and Dialysis, Bambino Gesù Children's Research Hospital, Rome, Italy.
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MeSH Terms
Bacterial Toxins / biosynthesis
Case-Control Studies
Child, Preschool
Escherichia coli / metabolism
Escherichia coli Infections / epidemiology*,  microbiology
Follow-Up Studies
Hemolytic-Uremic Syndrome / epidemiology*,  microbiology
Infant, Newborn
Italy / epidemiology
Retrospective Studies
Risk Factors
Shiga Toxin 1
Reg. No./Substance:
0/Bacterial Toxins; 0/Shiga Toxin 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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