Document Detail


Haemolytic, oedema and haemorrhage inducing activities of tentacular extract of the blubber jellyfish (Catostylus mosaicus).
MedLine Citation:
PMID:  1675964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. An extract prepared from the tentacle of the jellyfish (CE), Catostylus mosaicus exhibited haemolytic, oedema and haemorrhage-inducing activities. 2. Acetone treatment of the tentacle extract produced an acetone soluble extract (AE) which showed an increase in specific haemolytic and haemorrhagic activities by 25- and 120-fold respectively; the minimum oedema dose was reduced by 30-fold. 3. The AE caused a rapid onset of oedema in the mouse foot pad. The effect was long-lasting, reaching a maximum in about 30 min after injection and sustained up to 4 hr. 4. Fractionation of the AE on Q-Sepharose gave 4 bound fractions which induced oedema and haemorrhage; however only 3 of the fractions exhibited haemolytic activity.
Authors:
N Azila; F K Siao; I Othman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology     Volume:  99     ISSN:  0742-8413     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-01     Completed Date:  1991-08-01     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8310013     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Malaya, Kuala Lumpur.
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MeSH Terms
Descriptor/Qualifier:
Acetone
Animals
Chromatography, Ion Exchange
Cnidarian Venoms / isolation & purification,  toxicity*
Edema / chemically induced*
Hemolysis*
Hemorrhage / chemically induced*
Kaolin / toxicity
Kinetics
Mice
Povidone / toxicity
Rabbits
Solubility
Chemical
Reg. No./Substance:
0/Cnidarian Venoms; 1332-58-7/Kaolin; 67-64-1/Acetone; 9003-39-8/Povidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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