| Haemoglobin oxygen saturation as a biomarker: the problem and a solution. | |
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MedLine Citation:
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PMID: 22006898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Near-infrared spectroscopy measures of haemoglobin oxygen saturation are often used as an indicator of sufficient oxygen delivery to assess injury susceptibility and tissue damage. They have also often been used as a surrogate measure of oxygen metabolism. Unfortunately, these measures have generally failed to provide robust indicators of injury and metabolism. In this paper, we first review when haemoglobin oxygen saturation does work as a robust indicator, and then detail when and why it fails for assessing brain injury and breast cancer. Finally, we discuss the solution to obtain more robust measures of tissue injury and cancer by combining oxygen saturation measurements with measures of blood flow and volume to more accurately estimate oxygen metabolism. |
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Authors:
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David A Boas; Maria Angela Franceschini |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Volume: 369 ISSN: 1364-503X ISO Abbreviation: Philos Transact A Math Phys Eng Sci Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-18 Completed Date: 2012-01-03 Revised Date: 2012-01-24 |
Medline Journal Info:
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Nlm Unique ID: 101133385 Medline TA: Philos Transact A Math Phys Eng Sci Country: England |
Other Details:
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Languages: eng Pagination: 4407-24 Citation Subset: IM |
Affiliation:
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Optics Division of the Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 13th St rm 2301, Charlestown, MA 02129, USA. dboas@nmr.mgh.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / metabolism* Biophysics / methods Brain / metabolism Brain Injuries / diagnosis Breast / metabolism Breast Neoplasms / diagnosis Female Hemoglobins / metabolism* Humans Muscle, Skeletal / metabolism Muscles / metabolism Oxygen / chemistry, metabolism* Oxygen Consumption Spectroscopy, Near-Infrared / methods* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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P01-NS055104/NS/NINDS NIH HHS; P41-14075//PHS HHS; R01 HD042908-07/HD/NICHD NIH HHS; R01 HD042908-08/HD/NICHD NIH HHS; R01 HD042908-09/HD/NICHD NIH HHS; R01-EB06385/EB/NIBIB NIH HHS; R01-HD042908/HD/NICHD NIH HHS; R01-NS057476/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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