| Haemoglobin and anaemia in the SMART study. | |
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MedLine Citation:
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PMID: 21555815 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Data from randomized trials on the development of anaemia after interruption of therapy are not well-described. METHODS: A total of 2,248 patients from the SMART study were included. We used Cox proportional hazards models to investigate development of new (≤12 mg/dl for females and ≤14 mg/dl for males) or worsening (≤8 mg/dl if anaemic at randomization) anaemia and Poisson regression analyses to explore the relationship between anaemia and the development of AIDS, death or non-AIDS events. RESULTS: Overall, 759 patients developed new or worsening anaemia: 420/1,106 (38.0%) in the drug conservation (DC) arm and 339/1127 (30.1%) in the viral suppression (VS) arm (P<0.0001). At 4 months after randomization, patients in the DC arm had a significantly increased risk of developing new or worsening anaemia (adjusted relative hazard 1.56, 95% CI 1.28-1.89). Currently anaemic patients had an increased incidence of AIDS (adjusted incidence rate ratio [IRR] 2.31, 95% CI 1.34-3.98), death (adjusted IRR 2.19, 95% CI 1.23-3.87) and non-AIDS events (adjusted IRR 2.98, 95% CI 2.01-4.40) compared to non-anaemic patients. CONCLUSIONS: Patients who interrupted combination antiretroviral therapy had a higher risk of new or worsening anaemia. Anaemic patients had a higher incidence of AIDS, non-AIDS defining events or deaths, possibly due to deteriorating health and subclinical disease. |
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Authors:
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Amanda Mocroft; Alan R Lifson; Giota Touloumi; Jacqueline Neuhaus; Zoe Fox; Adrian Palfreeman; Michael J Vjecha; Sally Hodder; Stephane De Wit; Jens D Lundgren; Andrew N Phillips; |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Antiviral therapy Volume: 16 ISSN: 2040-2058 ISO Abbreviation: - Publication Date: 2011 |
Date Detail:
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Created Date: 2011-5-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815705 Medline TA: Antivir Ther Country: - |
Other Details:
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Languages: ENG Pagination: 329-337 Citation Subset: - |
Affiliation:
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University College Medical School, London, UK. a.mocroft@ucl.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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