Document Detail


Haemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetry.
MedLine Citation:
PMID:  20876330     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Haemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese family with this Hb variant and confirm its unusual clinical presentation. No evidence of haemolysis was seen. The absence of consistent abnormalities in routine Hb tests such as high-performance liquid chromatography and gel electrophoresis means that spurious hypoxaemia is the only clue to its presence, and genotypic analysis is the preferred method for definitive diagnosis. Its positive identification is important for counselling and will help to avoid unnecessary investigation and treatment for this benign condition.
Authors:
Chi-Chiu So; Amy Y Chan; Eudora Y Chow; Shek-Ying Lin; Sze-Fai Yip; Siu-Cheung Szeto; Li-Chong Chan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  63     ISSN:  1472-4146     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  947-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. scc@pathology.hku.hk
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