| Haemoglobin A1c in diagnosis of diabetes mellitus and pre-diabetes; validation by oral glucose tolerance test. The Tromsø OGTT Study. | |
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MedLine Citation:
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PMID: 22186659 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Haemoglobin A1c 6.5 % has recently been recommended by the World Health Organization (WHO) and the American Diabetes Association (ADA) as an alternative diagnostic criterion for diabetes mellitus (DM). Aim To evaluate HbA1c as an alternative to oral glucose tolerance test (OGTT) for diagnosis of DM and pre-diabetes and to find the optimal HbA1c cut off points for DM and pre-diabetes in our population. Subjects and Methods The subjects were recruited from the Tromsø Study, performed for the sixth time in 2007-2008 with 12 984 participants. All subjects with HbA1c in the range 5.8 - 6.9 % and a random sample of subjects with levels 5.3 - 5.7 % were invited to an OGTT. Results Among 3476 subjects who completed the OGTT, 199 were diagnosed with DM. The best sensitivity (69.8 %) and specificity (81.8 %) were found at HbA1c 6.2 %. For HbA1c 6.5 % we found a sensitivity of 34.7 % and specificity 97.1 %. The best cut off points for impaired fasting glucose (n=314) and impaired glucose tolerance (n=404) were found at HbA1c 5.9 % and 6.0 %, respectively. Pre-diabetes detected only by OGTT was associated with worse metabolic characteristics than pre-diabetes detected only by HbA1c. Conclusions The optimum HbA1c cut off point for DM in our population was lower than that proposed by WHO and ADA. To establish more precisely the HbA1c levels predictive of micro and macro-vascular complications long term prospective studies are needed. Population specific optimum cut off points may be necessary. |
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Authors:
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M S Hutchinson; R M Joakimsen; I Njølstad; H Schirmer; Y Figenschau; R Jorde |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, Tromsø, Norway and Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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