| Haemoglobin A(1c) cut-off point to identify a high risk group of future diabetes: results from the Omiya MA Cohort Study. | |
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MedLine Citation:
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PMID: 22248349 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: Using the HbA(1c) level to define diabetes has several advantages and these advantages also apply to define a high-risk group. However, the risk of diabetes increases as HbA(1c) increases and a certain degree of arbitrariness in the cut-off for the high risk group is unavoidable. The aim of this study was to determine the HbA(1c) cut-off for defining a high-risk group that corresponds to the fasting plasma glucose cut-off by comparing the risk of diabetes against the fasting plasma glucose and HbA(1c) levels in the Japanese population. Methods: A retrospective cohort study was conducted using data from annual health examinations performed in Omiya city. A total of 11 271 subjects between the ages of 40 and 79 years without diabetes at baseline were followed for up to 7 years. According to the new diagnostic criteria, diabetes was defined as an fasting plasma glucose level ≥ 7 mmol/l or an HbA(1c) level ≥ 48 mmol/mol (≥ 6.5%) or a self-report. The HbA(1c) cut-off corresponding to the fasting plasma glucose cut-off was determined using the incidence, hazard ratio, and a receiver operating characteristic analysis. Results: Eight hundred and sixty subjects developed diabetes. The incidence, hazard ratio, and receiver operating characteristic analysis all indicated that an HbA(1c) cut-off of 39 mmol/mol (5.7%) corresponded to an fasting plasma glucose level of 5.6 mmol/l. Conclusions: Our results suggested that the HbA(1c) cut-off for high-risk of diabetes should be 39 mmol/mol (5.7%), consistent with the American Diabetes Association recommendation. Further research is needed to determine whether our results are applicable to other populations. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. |
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Authors:
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M Kato; M Noda; H Suga; T Nakamura; M Matsumoto; Y Kanazawa; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-16 |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: - ISSN: 1464-5491 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. |
Affiliation:
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Japan Foundation for the Promotion of International Medical Research Cooperation Department of Diabetes and Metabolic Medicine, Center Hospital, and Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine Omiya Medical Association, Miyahara-cho, Kita-ku, Saitama-shi, Saitama Japan Diabetes Foundation, Hongo, Bunkyo-ku, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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