Document Detail

Haemodynamics in the first seconds after coronary artery occlusion.
MedLine Citation:
PMID:  1812975     Owner:  NLM     Status:  MEDLINE    
The changes in cardiac and in total haemodynamics, occurring during the first seconds of occlusion and the subsequent desocclusion of coronary arteries were studied on 28 dogs. The most intensive changes were observed after the trunk occlusion of the left coronary artery. Simultaneously with decreasing blood inflow into the myocardium its contractility and the systolic pressure in the left ventricle and the outflow from the coronary sinus began to fall rapidly. The systolic pressure in the left ventricle decreased within the first 10 s from 24 to 13-15 kPa (180 to 100-110 mm Hg), which means that the systolic pressure fell about 1 kPa (7-8 mm Hg) per second, or 0.5-0.6 kPa (4-5 mm Hg) per systole. At the same time the end-diastolic pressure in the left ventricle also increased from zero to 3-4 kPa (25-30 mm Hg). After the trunk desocclusion of the left coronary artery the systolic pressure in the left ventricle proceeded to fall by about 2-3 kPa (15-22 mm Hg). Only then, 20-25 s after the desocclusion, blood flow in the left coronary artery began to rise intensively and 4-6 s later the myocardial contractility and the systolic pressure in the left ventricle also increased. After unclamping (50-60 s), there was an overshoot of haemodynamic values above preocclusive values and then followed the compensatory phase. This phase lasted 80-90 s and on its peak the pressure and flow parameters increased by about 50-60% above preocclusive values. During the occlusion of ramus interventricularis anterior or ramus circumflexus for 30-60 s the haemodynamic parameters changed only slightly. The same was observed during trunk occlusion of the right coronary artery (30-60 s), but in that case many extrasystoles occurred.
J Antal; J Styk; I Gabauer; V Holec; D Pancza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  40     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  1991  
Date Detail:
Created Date:  1992-06-18     Completed Date:  1992-06-18     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  471-9     Citation Subset:  IM    
Institute of Heart Research, Slovak Academy of Sciences, Bratislava.
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MeSH Terms
Arterial Occlusive Diseases / physiopathology*
Blood Pressure
Carotid Artery Diseases / physiopathology*
Time Factors

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