Document Detail

Haemodynamics at rest and during isometric exercise under long-term treatment with captopril in dilated and ischaemic cardiomyopathy.
MedLine Citation:
PMID:  3308089     Owner:  NLM     Status:  MEDLINE    
In the present study 12 patients with severe chronic heart failure (7 with dilated cardiomyopathy and 5 with ischaemic heart disease) underwent right heart catheterization at rest and during isometric exercise by handgrip before and 6 months after treatment with captopril (mean dose 2 X 39.6 mg/day) while concomitant digitalis and diuretics were unchanged. After 6 months resting haemodynamics changed as follows: decrease in heart rate, mean arterial pressure, pulmonary capillary pressure and total vascular resistance; increase in stroke volume index and stroke work index. During handgrip the following changes were observed after captopril: decrease in total vascular resistance; increase in stroke volume index and stroke work index. Before captopril 11 patients showed no increase or even a decrease in stroke work index during isometric exercise, whereas after captopril 5 out of the 12 patients showed an increase in stroke work index. The results demonstrate that in patients with severe chronic heart failure long-term treatment with captopril lowers preload and afterload, which is accompanied by a significant improvement in left ventricular performance at rest. Furthermore, during isometric exercise after captopril an improvement in left ventricular function was found in 5 out of 12 patients.
P Greminger; P Eichhorn; O M Hess; W Vetter; H P Krayenbühl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  74     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-20     Completed Date:  1987-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  352-61     Citation Subset:  IM    
Department of Internal Medicine, Medical Policlinic, Zurich, Switzerland.
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MeSH Terms
Captopril / pharmacology*,  therapeutic use
Cardiomyopathy, Dilated / drug therapy,  physiopathology*
Coronary Disease / drug therapy,  physiopathology*
Hemodynamics / drug effects*
Isometric Contraction
Middle Aged
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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