| Haemodynamics at rest and during isometric exercise under long-term treatment with captopril in dilated and ischaemic cardiomyopathy. | |
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MedLine Citation:
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PMID: 3308089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study 12 patients with severe chronic heart failure (7 with dilated cardiomyopathy and 5 with ischaemic heart disease) underwent right heart catheterization at rest and during isometric exercise by handgrip before and 6 months after treatment with captopril (mean dose 2 X 39.6 mg/day) while concomitant digitalis and diuretics were unchanged. After 6 months resting haemodynamics changed as follows: decrease in heart rate, mean arterial pressure, pulmonary capillary pressure and total vascular resistance; increase in stroke volume index and stroke work index. During handgrip the following changes were observed after captopril: decrease in total vascular resistance; increase in stroke volume index and stroke work index. Before captopril 11 patients showed no increase or even a decrease in stroke work index during isometric exercise, whereas after captopril 5 out of the 12 patients showed an increase in stroke work index. The results demonstrate that in patients with severe chronic heart failure long-term treatment with captopril lowers preload and afterload, which is accompanied by a significant improvement in left ventricular performance at rest. Furthermore, during isometric exercise after captopril an improvement in left ventricular function was found in 5 out of 12 patients. |
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Authors:
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P Greminger; P Eichhorn; O M Hess; W Vetter; H P Krayenbühl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiology Volume: 74 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1987 |
Date Detail:
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Created Date: 1987-11-20 Completed Date: 1987-11-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 352-61 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Medical Policlinic, Zurich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Captopril
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pharmacology*,
therapeutic use Cardiomyopathy, Dilated / drug therapy, physiopathology* Coronary Disease / drug therapy, physiopathology* Female Hemodynamics / drug effects* Humans Isometric Contraction Male Middle Aged Rest |
| Chemical | |
Reg. No./Substance:
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62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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