Document Detail


Haemodynamic responses to sevoflurane compared with halothane during inhalational induction in children.
MedLine Citation:
PMID:  9365968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the haemodynamic changes during induction of anaesthesia in 50 ASA I and II children (1-12 yrs) undergoing minor elective surgery. The patients were randomly divided into two groups to receive either halothane (n = 25) or sevoflurane (n = 25) in a mixture of O2 and N2O (40:60) for mask induction of anaesthesia. Induction of anaesthesia was performed with an overpressure technique by administering rapid increases of gas concentrations, in increments of 1% up to 7% for sevoflurane and of 0.5% up to 3% for halothane. Induction was smooth and rapid in both groups but characterized by increases in heart rate and systolic blood pressure up to 20% especially in the sevoflurane group (P < 0.05); these increases in the latter group were significant compared with baseline and the halothane group (P < 0.05). No serious complications were observed. The authors conclude that more children experienced heart rate and blood pressure increases during the early stage of inhalational induction with sevoflurane compared with halothane.
Authors:
C Kern; T Erb; F J Frei
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  7     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  1997  
Date Detail:
Created Date:  1998-01-08     Completed Date:  1998-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Affiliation:
Department of Anaesthesia, University Hospital, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Anesthesia, Inhalation*
Anesthetics, Inhalation / administration & dosage*
Blood Pressure / drug effects*
Carbon Dioxide / metabolism
Chi-Square Distribution
Child
Child, Preschool
Ethers / administration & dosage*
Female
Halothane / administration & dosage*
Heart Rate / drug effects*
Humans
Infant
Male
Methyl Ethers*
Multivariate Analysis
Nitrous Oxide / administration & dosage
Oxygen / administration & dosage,  blood
Respiration / drug effects
Surgical Procedures, Elective
Surgical Procedures, Minor
Tidal Volume
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Ethers; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 151-67-7/Halothane; 28523-86-6/sevoflurane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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