| Haemodynamic response to nitrous oxide during high-dose fentanyl pancuronium anaesthesia. | |
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MedLine Citation:
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PMID: 3871999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten patients subjected to coronary by-pass surgery were studied to determine the haemodynamic effects of replacing Fio2 1.0 normoventilation with nitrous oxide in oxygen (Fio2 0.3) after induction of anaesthesia with fentanyl (50 micrograms/kg), flunitrazepam and pancuronium. In all patients the application of N2O decreased systemic arterial pressures by an average of 10% (P less than 0.001), but left pulmonary arterial pressures and systemic vascular resistance unchanged. The slight bradycardia induced was associated with moderate depression of the cardiac index and the left ventricular stroke work index (P less than 0.001) at the time when the rate-pressure product was decreased by 20% (P less than 0.001). The cardiac depression produced by N2O was most prominent in patients with left ventricular wall hypokinesia and an ejection fraction below 55%, in whom the cardiac work index was diminished by 29%. The replacement of oxygen with nitrous oxide in oxygen during high-dose fentanyl-pancuronium anaesthesia seems not to be associated with sympathetic stimulation, and the myocardial depressant effect of N2O should be weighed against the possible reduction in myocardial oxygen consumption with special care in patients with compromised myocardial function. |
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Authors:
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O A Meretoja; O Takkunen; H Heikkilä; U Wegelius |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 29 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-03-26 Completed Date: 1985-03-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, General* Blood Pressure / drug effects Coronary Artery Bypass Depression, Chemical Female Fentanyl* Heart Rate / drug effects Hemodynamics / drug effects* Humans Intraoperative Care Male Middle Aged Myocardium / metabolism Nitrous Oxide / pharmacology* Oxygen Consumption / drug effects Pancuronium* Preanesthetic Medication Stroke Volume / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Pancuronium; 10024-97-2/Nitrous Oxide; 437-38-7/Fentanyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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