Document Detail

Haemodynamic observations with KO. 1366 (bunitrolol), a new beta-adrenergic blocking agent.
MedLine Citation:
PMID:  22426     Owner:  NLM     Status:  MEDLINE    
The haemodynamic effects of a new beta-adrenergic blocking agent KO.1366 (bunitrolol) were assessed in 10 males admitted to hospital for investigation of chest pain. Measurements were made at rest, during atrial pacing at 100 beats/min, and during hand grip exercise, before and afterintravenous administration of KO.1366 at a dosage of 0.05 mg/kg body weight. There was a 12% (p less than 0.01) slowing in resting heart rate and alpha 4% (p less than 0.05) slowing in exercise heart rate after drug administration. Resting left ventricular end diastolic pressure rose by 2.2 mm Hg (p less than 0.01) following the drug, but there was no significant change during pacing or exercise. Left ventricular systolic pressure and its first derivative did not change significantly. Cardiac output rose slightly, and stroke volume at rest and during exercise showed a considerable increase. In the dosage used, KO.1366 has an important chronotropic effect on the heart without causing significant myocardial depression.
S O Banim; A da Silva; R Balcon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current medical research and opinion     Volume:  4     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1977  
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  630-4     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Disease / physiopathology
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Propanolamines / pharmacology*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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