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Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension.
MedLine Citation:
PMID:  20237500     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
We analysed the haemodynamic, metabolic and hormonal status at rest and in response to exercise, in young normotensive women with two hypertensive parents (FH++; n=17; 25.1±4.8 years), one hypertensive parent (FH+; n=18; 24.9±4.1 years) and normotensive parents (FH-; n=15; 25.3±3.8 years). Casual and ambulatorial blood pressure (BP), carotid-femoral pulse wave velocity (PWV) and biochemistry were analysed. BP, nor-epinephrine (NE), epinephrine (EPI), endothelin-1 (ET-1) and nitrite/nitrate (NOx) levels were also analysed during a graded exercise test (GXT). Casual and ambulatorial BP were not different between groups, but PWV was 7.5 and 12.6% higher in FH++ than FH+ and FH-, respectively, and 4.8% higher in FH+ than FH- (P≤0.01). Insulin and insulin-to-glucose ratio were increased in FH++ and FH+ (P<0.05), and low-density lipoprotein (LDL)-cholesterol tended to be higher only in FH++ (P=0.07). FH++ showed higher exercise and recovery diastolic BP and EPI levels, and increased resting, exercise and recovery NE, and ET-1 levels than FH- (P<0.05). FH+ showed only greater resting, exercise and recovery NE, and rest ET-1 (P<0.05). Resting, exercise and recovery NOx were lower in FH++ and FH+ than FH- (P<0.01). Haemodynamic, metabolic and hormonal abnormalities were presented in nonhypertensive young women offspring of hypertensive parents before any increase in BP. Greater abnormalities were observed in women with a strong family history of hypertension (FH++). These results suggest that there is an early vascular, metabolic and hormonal involvement in a familial hypertensive disorder.
Authors:
E G Ciolac; E A Bocchi; L A Bortolotto; V O Carvalho; J M D Greve; G V Guimarães
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-18
Journal Detail:
Title:  Journal of human hypertension     Volume:  24     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  814-22     Citation Subset:  IM    
Affiliation:
Heart Institute do HCFMUSP, São Paulo, Brazil. egciolac@hcnet.usp.br
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