Document Detail


Haemodynamic and metabolic effects of low daily dose sulphonylureas in diabetic dog hearts.
MedLine Citation:
PMID:  12189779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of glibenclamide (GB, CAS 10238-21-8) and those of the latest low daily dose sulphonylurea compound, glimepiride (GM, CAS 93479-97-1) on myocardial haemodynamics and pyruvate-lactate metabolism of healthy and alloxan-diabetic dogs (n = 6 in six groups) were compared. Mean arterial blood pressure, heart rate, blood flow of the left anterior descending coronary artery, myocardial contractile force, the rate of change of myocardial contraction and relaxation were measured and arterial (a. carotis communis) and venous (sinus coronarius) pyruvate and lactate concentrations were determined during i.v. administration of the drugs (0, 0.4, 2, 5, and 8 mumol/kg). Coronary conductivity, pressure-rate product and pyruvate-lactate extraction rates were calculated. Glimepiride reduced the heart rate in diabetic animals. Both compounds decreased myocardial contractile force, coronary blood flow and conductivity and the rate of change of myocardial contraction. However, alterations in blood pressure, pressure-rate product, the rate of change of myocardial relaxation and arterio-venous lactate difference elicited by glibenclamide proved to be more expressed than those by glimepiride. According to the results, glibenclamide and especially glimepiride do not enhance the disturbances of the cardiovascular system in diabetes. By this reason, considering its very low daily dose and favourable haemodynamic effects, glimepiride could preferably be recommended for the treatment of type 2 diabetics with coronary heart disease.
Authors:
Ildikó Pósa; Erzsébet Kocsis; Eva Nieszner; Gábor Pogátsa; Mária Zsófia Koltai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  52     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  2002  
Date Detail:
Created Date:  2002-08-22     Completed Date:  2002-09-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  552-9     Citation Subset:  IM    
Affiliation:
György Gottsegen National Institute of Cardiology, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Blood Pressure / drug effects
Coronary Circulation / drug effects
Diabetes Mellitus, Experimental / metabolism*,  physiopathology
Dogs
Female
Glyburide / pharmacology
Heart / drug effects*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypoglycemic Agents / pharmacology*
Lactic Acid / metabolism
Male
Myocardial Contraction / drug effects
Potassium / blood
Pyruvic Acid / metabolism
Sulfonylurea Compounds / pharmacology*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 0/Sulfonylurea Compounds; 10238-21-8/Glyburide; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 7440-09-7/Potassium; 93479-97-1/glimepiride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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