Document Detail


Haemodynamic and metabolic effects of the antiarrhythmic drug melperone during acute left ventricular failure in dogs.
MedLine Citation:
PMID:  7326689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Haemodynamic and metabolic effects of the new antiarrhythmic drug melperone were studied during acute ischaemic left ventricular failure in closed-chest anaesthetized dogs. Embolisation of the left main coronary artery with 50 micrometer plastic microspheres induced severe depression of left ventricular performance as evidenced by a marked increase in left ventricular end-diastolic pressure and a marked reduction in the maximum rate of left ventricular pressure rise (LVdP/dtmax), cardiac output, and stroke volume. Six dogs received intravenous melperone 1.0 and 2.5 mg . kg-1 (cumulative dose) 90 and 115 min after the embolisation, respectively. Six other dogs received no treatment and served as controls. Melperone effected a marked reduction in left ventricular end-diastolic pressure, a slight but transient increase in LVdP/dtmax, a moderate reduction in heart rate, a moderate reduction in mean aortic blood pressure and total peripheral resistance and a moderate increase in stroke volume. Melperone moderately decreased myocardial O2-consumption, while myocardial lactate uptake remained unchanged. In conclusion, in contrast to commonly used antiarrhythmic drugs which may all induce cardiodepression, melperone improved left ventricular function in dogs with acute ischaemic left ventricular failure.
Authors:
O A Smiseth; E S Platou; H Refsum; O D Mjøs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  15     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  724-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Anti-Arrhythmia Agents / pharmacology*,  therapeutic use
Butyrophenones / pharmacology*,  therapeutic use
Coronary Disease / drug therapy,  metabolism,  physiopathology*
Dogs
Female
Hemodynamics / drug effects*
Male
Myocardium / metabolism*
Oxygen Consumption / drug effects
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Butyrophenones; 3575-80-2/metylperon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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