Document Detail

Haemodynamic long-term effects of metoprolol at rest and during exercise in essential hypertension.
MedLine Citation:
PMID:  861129     Owner:  NLM     Status:  MEDLINE    
1 Twelve men with untreated essential hypertension in WHO stage I were studied on an outpatient basis to evaluate the haemodynamic long-term effect of a new beta-adrenoceptor blocker, metoprolol. 2 Oxygen consumption, heart rate, cardiac output (Cardiogreen) and intraarterial brachial pressure were recorded at rest in a supine and sitting position and during steady state work at 300, 600 and 900 kpm/min. 3 The subjects were treated with metoprolol (dose 50-250 mg/day) as the sole drug for 1 year and the haemodynamic study was repeated. 4 Mean arterial blood pressure was reduced about 12% at rest and 9% during exercise. The heart rate was decreased about 22% at rest and 20% during exercise. There was no significant compensatory increase in the stroke volume and consequently the cardiac index was reduced about 22% at rest sitting and about 17% during exercise. There was no decrease in total peripheral resistance. 5 No side-effects were seen. 6 The major haemodynamic long-term effects of metoprolol in mild and moderate essential hypertension resemble those seen by other beta-adrenoceptor blockers like alprenolol, atenolol and timolol. The study has not given support to the assumption that metoprolol should cause less depression in cardiac output than other beta-adrenoceptor blockers.
P Lund-Johansen; O J Ohm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  4     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM; S    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / physiopathology*
Metoprolol / pharmacology*
Middle Aged
Oxygen Consumption / drug effects
Physical Exertion*
Propanolamines / pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Propanolamines; 37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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