Document Detail

Haemodynamic and hormonal responses to oral enalapril in salt depleted normotensive man.
MedLine Citation:
PMID:  8471406     Owner:  NLM     Status:  MEDLINE    
A combination of dietary sodium restriction (40 mmol day-1) and frusemide pretreatment has been used to activate the renin angiotensin system (RAS) in order to characterise the haemodynamic and hormonal responses to enalapril in young normotensives. Enalapril significantly reduced supine blood pressure with a mean maximum fall of 19 +/- 7.6, compared with 6.5 +/- 6.8 mm Hg with placebo. Similar but greater responses were seen in erect blood pressure. Mean maximal plasma ACE inhibition (78 +/- 5.7%) was associated with a significant increase in PRA from 5.2 +/- 2.1 ngAI ml-1 h-1 to a peak of 29.1 +/- 6 ngAI ml-1 h-1. This simple well tolerated regimen produced consistent RAS activation and gave readily measurable falls in blood pressure following enalapril. This model may be used to undertake detailed assessments of ACE inhibition, renin inhibition and angiotensin receptor blockade.
R J MacFadyen; H L Elliott; P A Meredith; J L Reid
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  35     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-14     Completed Date:  1993-05-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-301     Citation Subset:  IM    
University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow.
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MeSH Terms
Analysis of Variance
Blood Pressure / drug effects
Diet, Sodium-Restricted
Double-Blind Method
Enalapril / blood,  pharmacology*
Furosemide / pharmacology
Heart Rate / drug effects
Hemodynamics / drug effects*
Potassium / urine
Renin / blood
Renin-Angiotensin System / drug effects*
Sodium / deficiency*
Reg. No./Substance:
54-31-9/Furosemide; 7440-09-7/Potassium; 7440-23-5/Sodium; 75847-73-3/Enalapril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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