| Haemodynamic and hormonal responses to oral enalapril in salt depleted normotensive man. | |
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MedLine Citation:
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PMID: 8471406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A combination of dietary sodium restriction (40 mmol day-1) and frusemide pretreatment has been used to activate the renin angiotensin system (RAS) in order to characterise the haemodynamic and hormonal responses to enalapril in young normotensives. Enalapril significantly reduced supine blood pressure with a mean maximum fall of 19 +/- 7.6, compared with 6.5 +/- 6.8 mm Hg with placebo. Similar but greater responses were seen in erect blood pressure. Mean maximal plasma ACE inhibition (78 +/- 5.7%) was associated with a significant increase in PRA from 5.2 +/- 2.1 ngAI ml-1 h-1 to a peak of 29.1 +/- 6 ngAI ml-1 h-1. This simple well tolerated regimen produced consistent RAS activation and gave readily measurable falls in blood pressure following enalapril. This model may be used to undertake detailed assessments of ACE inhibition, renin inhibition and angiotensin receptor blockade. |
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Authors:
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R J MacFadyen; H L Elliott; P A Meredith; J L Reid |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 35 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-05-14 Completed Date: 1993-05-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 299-301 Citation Subset: IM |
Affiliation:
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University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Blood Pressure / drug effects Diet, Sodium-Restricted Double-Blind Method Enalapril / blood, pharmacology* Furosemide / pharmacology Heart Rate / drug effects Hemodynamics / drug effects* Humans Potassium / urine Renin / blood Renin-Angiotensin System / drug effects* Sodium / deficiency* |
| Chemical | |
Reg. No./Substance:
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54-31-9/Furosemide; 7440-09-7/Potassium; 7440-23-5/Sodium; 75847-73-3/Enalapril; EC 3.4.23.15/Renin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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