| Haemodynamic and hormonal responses to losartan (DuP753/MK954) infusion during cardiac catheterization in conscious salt-deplete dogs. | |
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MedLine Citation:
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PMID: 8403784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Haemodynamic and hormonal responses to infused angiotensin II were studied in conscious salt-deplete dogs during infusion of D-glucose or losartan (DuP753/MK954). 2. Mean arterial pressure (118 +/- 13 mmHg) fell rapidly after losartan (60 min 106 +/- 18 mmHg) with a rise in heart rate (107 +/- 16 beats/min) from baseline (98 +/- 17 beats/min). Pressor responses to angiotensin II during D-glucose infusion (6 ng min-1 kg-1, 99 +/- 10 mmHg; 18 ng min-1 kg-1, 140 +/- 15 mmHg; 54 ng min-1 kg-1, 157 +/- 12 mmHg; 162 ng min-1 kg-1, 178 +/- 14 mmHg) showed a parallel shift during losartan infusion with very similar pressures in response to higher rates of angiotensin II infusion (54 ng min-1 kg-1, 108 +/- 17 mmHg; 162 ng min-1 kg-1, 138 +/- 14 mmHg; 486 ng min-1 kg-1, 155 +/- 14 mmHg; 1458 ng min-1 kg-1, 177 +/- 12 mmHg). Losartan caused a fall in baseline systemic vascular resistance. Despite the similar mean arterial pressure, the rise in systemic vascular resistance after angiotensin II during D-glucose infusion (162 ng min-1 kg-1, 8065 +/- 1967 dyn s cm-5) was reduced during losartan infusion (1458 ng min-1 kg-1, 6645 +/- 1720 dyn s cm-5. Losartan caused a small rise in cardiac output related to a rise in heart rate and increased stroke volume. Pressure infusions of angiotensin II caused a fall in cardiac output during D-glucose infusion, which was blocked during losartan infusion.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R J MacFadyen; M Tree; A F Lever; J L Reid |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 85 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-11-02 Completed Date: 1993-11-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 157-63 Citation Subset: IM |
Affiliation:
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University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood* Angiotensin II / antagonists & inhibitors*, blood, pharmacology Animals Biphenyl Compounds / pharmacology* Blood Pressure / drug effects Dogs Dose-Response Relationship, Drug Heart Catheterization Heart Rate / drug effects Hemodynamics / drug effects* Imidazoles / pharmacology* Losartan Male Stimulation, Chemical Tetrazoles / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Biphenyl Compounds; 0/Imidazoles; 0/Tetrazoles; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 52-39-1/Aldosterone |
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