| Haemodynamic effects of water-soluble contrast media on the isolated perfused rat kidney. | |
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MedLine Citation:
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PMID: 2036568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The precise mechanism underlying the nephrotoxicity of radiocontrast media remains ill defined. In this study we have examined the direct effect of a wide range of low- and high-osmolar water-soluble contrast media (WSCM) on the vascular resistance of the isolated perfused rat kidney (IPRK). Water-soluble contrast media led to a significant fall in the renal perfusate flow and an increase in the renal vascular resistance (RVR). The magnitude of these haemodynamic changes was independent of the osmolality of the tested agents. This study shows a direct effect of WSCM on the vascular resistance of the isolated perfused rat kidney. |
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Authors:
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A A el Sayed; J L Haylor; A M el Nahas; S Salzano; S K Morcos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of radiology Volume: 64 ISSN: 0007-1285 ISO Abbreviation: Br J Radiol Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-07-03 Completed Date: 1991-07-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 435-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine and Pharmacology, University of Sheffield, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media / adverse effects* Hemodynamics / drug effects Kidney / blood supply, drug effects* Male Osmolar Concentration Perfusion Rats Rats, Inbred Strains Vascular Resistance / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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