Document Detail

Haemodynamic effects of thoracic epidural anaesthesia during proximal aortic cross-clamping in pigs.
MedLine Citation:
PMID:  7725879     Owner:  NLM     Status:  MEDLINE    
Cross-clamping (XC) of the thoracic aorta induces a hyperdynamic circulation proximal to the aortic clamp. In this investigation, the effects of thoracic epidural anaesthesia (TEA) on the haemodynamic response to XC were studied in pigs. Seventeen pigs were anaesthetized with ketamine, and the thoracic aorta was cross-clamped for 30 minutes. In eight of the animals (TEA-group) a thoracic epidural block (3 ml 0.5% bupivacaine) was added to the general anaesthesia. Prior to XC there was a lower heart rate (HR), cardiac output (CO) and mixed venous oxygen saturation (SvO2) in the TEA-group compared to the nine animals with general anasthesia only (control-group). During XC there was an increase in HR, CO, SvO2 and proximal aortic blood pressure (PPROX) in both groups, without differences between groups. Following aortic declamping central venous pressure (CVP), pulmonary artery pressure (PAP) and pulmonary capillary wedge pressure (PCWP) increased in both groups. Fifteen minutes after declamping, one animal in each group died. It was concluded that in this experimental model, TEA combined with general anaesthesia did not modify the haemodynamic response to XC of the thoracic aorta.
P Aadahl; O D Saether; R Stenseth; H O Myhre
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  39     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-22     Completed Date:  1995-05-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
Department of Anaesthesiology, Trondheim University Hospital, Norway.
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MeSH Terms
Anesthesia, Epidural*
Anesthesia, General
Aorta, Thoracic / physiopathology,  surgery*
Blood Pressure / physiology
Bupivacaine / administration & dosage
Carbon Dioxide / blood
Cardiac Output / physiology
Central Venous Pressure / physiology
Heart Rate / physiology
Hemodynamics / physiology*
Ketamine / administration & dosage
Oxygen / blood
Pulmonary Artery / physiology
Pulmonary Wedge Pressure / physiology
Regional Blood Flow / physiology
Thoracic Vertebrae
Reg. No./Substance:
124-38-9/Carbon Dioxide; 2180-92-9/Bupivacaine; 6740-88-1/Ketamine; 7782-44-7/Oxygen

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