Document Detail


Haemodynamic effects of short term intravenous amiodarone for hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  3370179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The haemodynamic effects of an intravenous amiodarone infusion (5 mg/kg for 10 minutes) were measured in ten patients with hypertrophic cardiomyopathy (two with a left ventricular outflow gradient at rest) five, 15, and 30 minutes after drug administration. Mean (SD) pulmonary capillary wedge pressure rose significantly at five and 15 minutes (from 12.3 (6.2) mm Hg to 17.6 (9.2) and to 16.2 (8.6] with a subsequent tendency to fall to control values at 30 minutes. Mean right atrial and right ventricular end diastolic pressures increased from 3.6 (1.8) mm Hg to 7.3 (3.1) and from 6.3 (2.4) to 9.8 (3.2) mm Hg respectively at 30 minutes. The increase in filling pressures was paralleled by a decrease of left ventricular max dP/dt from 1522 (414) to 1372 (327) to 1316 (338) and to 1326 (379) five, 15, and 30 minutes after infusion. Despite this slight negative inotropic effect, cardiac index and stroke volume index were unchanged or slightly increased, possibly because of the decrease in systemic vascular resistance (from 1326 (330) dyn s cm-5/m2 to 1152 (285]. In both patients with outflow gradient the pressure gradient at rest decreased (from 110 to 65 and from 85 to 65 mm Hg) through a reduction of left ventricular systolic pressure. Thus short term intravenous infusion of amiodarone is safe in patients with hypertrophic cardiomyopathy. The main changes were a mild depression of ventricular contractility, which was well tolerated and adequately compensated for by a decrease in afterload.
Authors:
A Branzi; C Rapezzi; P M Benenati; G Binetti; G Piovaccari; M Bacchi; R Roncuzzi; R Zannoli; B Magnani
Related Documents :
11118399 - Lack of agreement between central venous pressure and pulmonary capillary wedge pressur...
10523369 - Responses to acute changes in arterial pressure on renal medullary nitric oxide activit...
20621249 - Lower blood pressure goals in high-risk cardiovascular patients: are they defensible?
16677879 - Splanchnic perfusion pressure: a better predictor of safe primary closure than intraabd...
4084039 - Methylmethacrylate blood levels in patients with femoral neck fracture.
8621179 - Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: effects on ...
961449 - Prostaglandins, a link between renal hydro- and hemodynamic in dogs.
11714549 - Do the intervertebral disc cells respond to different levels of hydrostatic pressure?
16726109 - The use of catheter-tipped pressure transducers for chronic measurement of genital trac...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  59     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-27     Completed Date:  1988-06-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  446-52     Citation Subset:  AIM; IM    
Affiliation:
Istituto di Malattie dell'Apparato Cardiovascolare, Università degli Studi di Bologna, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Amiodarone / administration & dosage,  pharmacology*,  therapeutic use
Cardiomyopathy, Hypertrophic / drug therapy*,  physiopathology
Female
Hemodynamics / drug effects*
Humans
Infusions, Intravenous
Male
Middle Aged
Chemical
Reg. No./Substance:
1951-25-3/Amiodarone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The 1987 USA National CAPD Registry report.
Next Document:  Cryoablation of the accessory pathway in Wolff-Parkinson-White syndrome: initial results and long te...