| Haemodynamic effects of a selective adenosine A2A receptor agonist, CGS 21680, in chronic heart failure in anaesthetized rats. | |
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MedLine Citation:
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PMID: 9831898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Recently we demonstrated that the administration of an A2A adenosine receptor agonist, CGS 21680, to anaesthetized rats with acute heart failure (1 h post-coronary artery ligation) resulted in an increase in cardiac output. In the present investigation, the effects of CGS 21680 on cardiac output, vascular resistance, heart rate, blood pressure and mean circulatory filling pressure (Pmcf) were investigated in anaesthetized rats with chronic heart failure (8 weeks post-coronary artery ligation). 2. Experiments were conducted in five groups (n = 6) of animals: sham-operated vehicle-treated (0.9% NaCl; 0.037 mL kg(-1) min(-1)) animals in which the occluder was placed but not pulled to ligate the coronary artery; coronary artery-ligated vehicle-treated animals; and coronary artery-ligated CGS 21680-treated (0.1. 0.3 or 1.0 microg kg(-1) min(-1)) animals. 3. Baseline blood pressure, cardiac output and rate of rise in left ventricular pressure (+dP/dt) were significantly reduced in animals with coronary artery ligation when compared to sham-operated animals. Coronary artery ligation resulted in a significant increase in left ventricular end-diastolic pressure, Pmcf and venous resistance when compared to sham-operated animals. 4. Administration of CGS 21680 at 0.3 and 1.0 microg kg(-1) min(-1) significantly (n = 6; P<0.05) increased cardiac output by 19+/-4% and 39+/-5%, and heart rate by 14+/-2% and 15+/-1%, respectively, when compared to vehicle treatment in coronary artery-ligated animals. Administration of CGS 21680 also significantly reduced blood pressure and arterial resistance when compared to coronary artery-ligated vehicle-treated animals. Infusion of CGS 21680 also significantly reduced venous resistance when compared to vehicle-treated coronary artery-ligated animals. 5. The results show that heart failure is characterized by reduced cardiac output, and increased left ventricular end-diastolic pressure, venous resistance and Pmcf. Acute treatment with CGS 21680 in animals with chronic heart failure decreased left ventricular end-diastolic pressure and increased cardiac output. This increase in cardiac output was the result of reduced arterial and venous resistances and increased heart rate. |
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Authors:
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A A Nekooeian; R Tabrizchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of pharmacology Volume: 125 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-03-25 Completed Date: 1999-03-25 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 651-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, Vancouver, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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analogs & derivatives*,
pharmacology Anesthesia Animals Antihypertensive Agents / pharmacology* Blood Pressure / drug effects Body Weight Cardiac Output / drug effects Coronary Disease / physiopathology Heart Failure / physiopathology* Heart Rate / drug effects Hemodynamics / drug effects* Ligation Male Organ Size Phenethylamines / pharmacology* Rats Rats, Sprague-Dawley Receptor, Adenosine A2A Receptors, Purinergic P1 / agonists* Time Factors Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Phenethylamines; 0/Receptor, Adenosine A2A; 0/Receptors, Purinergic P1; 120225-54-9/CGS 21680; 58-61-7/Adenosine |
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