Document Detail

Haemodynamic effects on the myocardial blood flow supply/oxygen demand ratio in pacing induced angina pectoris.
MedLine Citation:
PMID:  698987     Owner:  NLM     Status:  MEDLINE    
Angina pectoris results from an imbalance between oxygen supply and demand in the subendocardium. The haemodynamic effects contributing to this imbalance have been studied in 10 patients with coronary artery disease. Myocardial oxygen demand was estimated from the tension time index (TTI), potential subendocardial flow from a diastolic pressure time index (DPTI), and the oxygen supply/demand ratio from (DPTI/TTI. With progressively increasing pacing rates up until induction of angina, no significant change in TTI was found whereas a significant fall in DPTI and DPTI/TTI occurred (P less than 0.001). During pacing runs with induction of angina DPTI/TTI reached a minimum value 5 s before,and at the onset of angina. No such relationship was seen for TTI or DPTI alone. A significant rise in LVEDP (P less than 0.05) and fall in dP/dt min (P less than 0.01) occurred at angina both contributing to a further reduction in DPTI and DPTI/TTI. Changes in DPTI/TTI may then reflect changes in the myocardial blood flow supply/oxygen demand ratio in the presence of coronary artery disease and haemodynamic changes before and at the induction of angina lead to a further reduction of this ratio.
D C Russell; R Balcon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  12     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  358-63     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris / etiology,  metabolism,  physiopathology*
Cardiac Pacing, Artificial / adverse effects
Coronary Circulation
Oxygen Consumption

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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