| Haemodynamic effects of midazolam in the anaesthetized patient with coronary artery disease. | |
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MedLine Citation:
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PMID: 6138915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The haemodynamic effects of midazolam 0.25 mg/kg administered intravenously were studied in eight anaesthetized patients suffering from coronary artery disease. Heart rate, systemic and pulmonary pressures, right atrial pressure, capillary pressure and cardiac output were measured 2, 5, 8 and 12 min after injection of midazolam and were compared with reference values collected before the commencement of the haemodynamic test. The cardiovascular condition of all the patients followed the same course after the injection of midazolam. The greatest variations were seen at the twelfth minute, with the exception of capillary pressure where the largest decrease was noted at the eighth minute. These variations, expressed as a percentage of the initial values, were: mean arterial pressure -17% (P less than 0.01); capillary pressure -23.5% (eight minute, P less than 0.01); heart rate - 9% (P less than 0.01); cardiac index -9% (P less than 0.01); systemic vascular resistance -12% (eighth minute, P less than 0.01). The stroke volume was well maintained (+0.1% NS). These haemodynamic variations were accompanied by a favourable evolution of the endocardial viability ratio (EVR), +12% (P less than 0.01). The slight tachycardia occasionally seen on induction of anaesthesia with midazolam was not seen in this group of patients. We conclude that these haemodynamic variations leading to an increase in EVR support the use of midazolam as a supplement to fentanyl anaesthesia for patients with coronary artery disease. |
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Authors:
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J Massaut; A d'Hollander; L Barvais; J Dubois-Primo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 27 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 299-302 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, General* Anti-Anxiety Agents / pharmacology* Benzodiazepines / pharmacology* Blood Pressure / drug effects Cardiac Output / drug effects Coronary Disease / physiopathology* Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Male Midazolam Middle Aged Pulmonary Circulation / drug effects Stroke Volume / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 12794-10-4/Benzodiazepines; 59467-70-8/Midazolam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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