| Haemodynamic effects of intravenous sotalol in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 3539617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are few placebo controlled studies in acute myocardial infarction concerning the haemodynamic effects of beta blockade. In a controlled, double-blind randomized study, the haemodynamic effects of sotalol were evaluated in 20 patients with acute myocardial infarction within 24 hours of the onset. Sotalol was administered to 10 patients over 12 hours by a continuous infusion including three different infusion rates. A serum level around 1.4 microgram ml-1 was achieved after one hour of infusion. The placebo patients were given saline infusion. The patients were monitored invasively using a thermodilution catheter in the pulmonary artery. In the sotalol group, there was a significant reduction in heart rate, systolic blood pressure, cardiac output and stroke volume compared to placebo. A slight increase in the mean pressures of right atrium, pulmonary artery systolic and diastolic pressures was also seen. The infusion was well tolerated and no adverse reaction was seen. |
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Authors:
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M Aström; O Edhag; O Nyquist; H Vallin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European heart journal Volume: 7 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1987-02-03 Completed Date: 1987-02-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 931-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Clinical Trials as Topic Creatine Kinase / blood Double-Blind Method Electrocardiography Hemodynamics / drug effects* Humans Infusions, Intravenous Middle Aged Myocardial Infarction / drug therapy*, physiopathology Random Allocation Sotalol / administration & dosage, therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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3930-20-9/Sotalol; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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