Document Detail

Haemodynamic effects of intravenous nicardipine during upright exercise in patients with stable angina pectoris.
MedLine Citation:
PMID:  6527973     Owner:  NLM     Status:  MEDLINE    
The immediate haemodynamic effects, at rest and during exercise, of 2.5 and 10mg intravenous nicardipine were measured in 20 male patients with uncomplicated angina pectoris due to angiographically confirmed coronary artery disease. At rest, both doses of nicardipine resulted in reductions in the systemic arterial pressure and vascular resistance and increases in heart rate and cardiac output. The changes were greater after the larger than after the smaller dose of nicardipine. During exercise, neither dose of nicardipine resulted in a substantial change in the haemodynamic profile, except that after the larger dose heart rate and cardiac output were higher than in the control study. These results indicate that the major overall haemodynamic effect of intravenous nicardipine is dilatation of the systemic arteriolar resistance vessels associated with reflex increase in cardiac pumping activity.
N C Jackson; B Silke; S P Verma; G Reynolds; M Hafizullah; S H Taylor
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  60 Suppl 4     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1984  
Date Detail:
Created Date:  1985-04-19     Completed Date:  1985-04-19     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM; S    
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MeSH Terms
Angina Pectoris / physiopathology*
Blood Pressure / drug effects
Calcium Channel Blockers / pharmacology*
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Nifedipine / analogs & derivatives*,  pharmacology
Physical Exertion*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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