Document Detail

Haemodynamic effects of intravenous diltiazem at rest and exercise in patients with coronary artery disease.
MedLine Citation:
PMID:  6745287     Owner:  NLM     Status:  MEDLINE    
The acute effects of intravenous diltiazem on exercise performance were studied in 10 patients with coronary artery disease. Haemodynamic measurements were made at rest and during exercise before and after 0.5 mg kg-1 of diltiazem. Diltiazem prolonged the duration of exercise (+2.85 min, P less than 0.001) and delayed the onset of ischaemic ST depression or angina in all patients. The highest tolerated heart rate and pressure rate product were increased in all but one patient after diltiazem. At rest diltiazem decreased mean arterial pressure (-10.8%, P less than 0.005), systemic vascular resistance (SVR) (-11.8%, P less than 0.05) and left ventricular stroke work index (SWI) (-14.1%, P less than 0.005). During exercise under diltiazem therapy, at the level achieved before the drug, the pulmonary capillary wedge pressure (-30%, P less than 0.005) and the SVR (-13.6%, P less than 0.02) were lowered, the SWI (+13%, P less than 0.01) was increased; at the end of exercise only the SVR (-14%, P less than 0.05) was reduced. Two patients experienced angina on lying down and one had orthostatic hypotension after exercise with diltiazem. This study indicates that intravenous diltiazem is a potentially useful agent for the treatment of angina by reducing myocardial oxygen demand at rest and by improving left ventricular performances on exercise.
V Legrand; F Hastir; M Vandormael; P Collignon; H E Kulbertus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  5     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-09-14     Completed Date:  1984-09-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  456-63     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris / drug therapy*
Benzazepines / pharmacology*
Coronary Disease / drug therapy,  physiopathology*
Coronary Vessels / drug effects*
Diltiazem / adverse effects,  pharmacology*,  therapeutic use
Heart / drug effects
Hemodynamics / drug effects*
Middle Aged
Physical Exertion
Vascular Resistance / drug effects
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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