Document Detail

Haemodynamic effects of intravenous clonidine on propofol or thiopental induction.
MedLine Citation:
PMID:  10695907     Owner:  NLM     Status:  MEDLINE    
The study evaluated the effects of premedication with intravenous clonidine on thiopental or propofol requirements for induction and haemodynamic changes associated with both induction and endotracheal intubation. Clonidine administered intravenously before induction of anaesthesia reduced propofol or thiopental requirements. The association of clonidine and propofol caused, after injection of the induction drug, a decrease in mean arterial pressure which was significantly greater than with thiopental. Moreover, a major haemodynamic stability was registered before and after laryngoscopy in the clonidine-thiopental group. These findings might contraindicate the clonidine-propofol combination in patients with cardiovascular disease.
F Marinangeli; C Cocco; A Ciccozzi; A Ciccone; F Donatelli; G Facchetti; A Paladini; A Pasqualucci; G Varrassi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  44     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-09     Completed Date:  2000-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  150-6     Citation Subset:  IM    
Department of Anaesthesiology, Intensive Care and Pain Management, University of L'Aquila, Coppito, Italy.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Anesthetics, Intravenous / pharmacology*
Blood Pressure / drug effects
Clonidine / pharmacology*
Double-Blind Method
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Preanesthetic Medication*
Propofol / pharmacology*
Thiopental / pharmacology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 4205-90-7/Clonidine; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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