Document Detail


Haemodynamic effects of inosine. A new drug for failing human heart?
MedLine Citation:
PMID:  2594615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Haemodynamic effects of inosine were studied in intact dogs and subsequently in patients suffering from prolonged otherwise intractable cardiogenic shock. The nucleoside significantly improve myocardial performance in patients with an extremely low cardiac index by 63 +/- 29% as well as animals with no signs of haemodynamic deterioration, increasing cardiac output by 12.2 +/- 4.3%. These results suggest that inosine may become a promising inotropic agent. Further studies though are necessary to elucidate the mechanism of inosine action.
Authors:
W Czarnecki; A Czarnecki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  21     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:    1989 Sep-Oct
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  587-94     Citation Subset:  IM    
Affiliation:
II Department of Cardiology, Grochowski Hospital, Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Animals
Blood Pressure / drug effects
Cardiac Output / drug effects
Dogs
Female
Heart Catheterization
Heart Failure / drug therapy*,  physiopathology
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Inosine / pharmacology*,  therapeutic use
Male
Middle Aged
Myocardial Contraction / drug effects
Pulmonary Circulation / drug effects
Shock, Cardiogenic / physiopathology
Chemical
Reg. No./Substance:
58-63-9/Inosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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