| Haemodynamic effects of hydrallazine and of hydrallazine plus glyceryl trinitrate paste in heart failure. | |
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MedLine Citation:
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PMID: 99155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a study designed to investigate potential non-parenteral treatment for chronic heart failure, hydrallazine, 225 to 300 mg per day, was given orally to 9 patients. There was no significant change in heart rate or mean arterial pressure as cardiac output increased. Left ventricular stroke work increased significantly and pulmonary artery wedge pressure fell. Systemic and pulmonary vascular resistances fell. With the addition of 2 per cent glyceryl trinitrate paste, there was a further decline in mean pulmonary arterial and wedge pressures, without a significant change in heart rate, arterial pressures, cardiac output, or systemic or pulmonary vascular resistance. There were no untoward effects from either form of treatment. All patients reported relief of shortness of breath and other symptoms related to ventricular dysfunction. This study supports the suggestion that oral hydrallazine is effective in increasing cardiac output and decreasing pulmonary congestion. Furthermore, the addition of topical glyceryl trinitrate provides a greater reduction of pulmonary pressures, probably through its predominant venodilator action. In some selected patients with heart failure, oral hydrallazine and topical glyceryl trinitrate in combination produce beneficial clinical and haemodynamic effects, probably through afterload and preload reduction, respectively. |
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Authors:
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J Mehta; C J Pepine; C R Conti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British heart journal Volume: 40 ISSN: 0007-0769 ISO Abbreviation: Br Heart J Publication Date: 1978 Aug |
Date Detail:
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Created Date: 1978-12-02 Completed Date: 1978-12-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370634 Medline TA: Br Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 845-50 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure / drug effects Cardiac Output / drug effects Drug Therapy, Combination Heart Failure / drug therapy* Humans Hydralazine / pharmacology, therapeutic use* Male Middle Aged Nitroglycerin / pharmacology, therapeutic use* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin; 86-54-4/Hydralazine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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