Document Detail


Haemodynamic effects of hydrallazine and of hydrallazine plus glyceryl trinitrate paste in heart failure.
MedLine Citation:
PMID:  99155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a study designed to investigate potential non-parenteral treatment for chronic heart failure, hydrallazine, 225 to 300 mg per day, was given orally to 9 patients. There was no significant change in heart rate or mean arterial pressure as cardiac output increased. Left ventricular stroke work increased significantly and pulmonary artery wedge pressure fell. Systemic and pulmonary vascular resistances fell. With the addition of 2 per cent glyceryl trinitrate paste, there was a further decline in mean pulmonary arterial and wedge pressures, without a significant change in heart rate, arterial pressures, cardiac output, or systemic or pulmonary vascular resistance. There were no untoward effects from either form of treatment. All patients reported relief of shortness of breath and other symptoms related to ventricular dysfunction. This study supports the suggestion that oral hydrallazine is effective in increasing cardiac output and decreasing pulmonary congestion. Furthermore, the addition of topical glyceryl trinitrate provides a greater reduction of pulmonary pressures, probably through its predominant venodilator action. In some selected patients with heart failure, oral hydrallazine and topical glyceryl trinitrate in combination produce beneficial clinical and haemodynamic effects, probably through afterload and preload reduction, respectively.
Authors:
J Mehta; C J Pepine; C R Conti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  40     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  845-50     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure / drug effects
Cardiac Output / drug effects
Drug Therapy, Combination
Heart Failure / drug therapy*
Humans
Hydralazine / pharmacology,  therapeutic use*
Male
Middle Aged
Nitroglycerin / pharmacology,  therapeutic use*
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin; 86-54-4/Hydralazine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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