Document Detail


Haemodynamic effects of eprosartan and valsartan in hypertensive patients during isometric and mental stress.
MedLine Citation:
PMID:  16148617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the effects of eprosartan and valsartan on the haemodynamics of forearm circulation in hypertensives undergoing isometric and mental stress. DESIGN AND METHODS: Thirty-six patients with essential stable hypertension underwent haemodynamic evaluations on the left arm: humeral flux and calibre by means of colour Doppler ultrasound, microcirculatory flux on the third finger of left hand by means of laser Doppler flowmetry, blood pressure and heart rate monitor. District resistance was calculated as the ratio between mean arterial pressure and blood flow, and microcirculatory conductance was calculated as the ratio between flux and the mean pressure. The evaluations were performed at rest, during handgrip and during mental stress. Patients were randomized to receive eprosartan (600 mg) or valsartan (160 mg); tests were repeated after 15 days of therapy. RESULTS: Both treatments reduced blood pressure (P<0.05) and peripheral resistance during tests. Eprosartan obtained a greater reduction in resistance during handgrip than valsartan. Laser Doppler flowmetry showed a significant decrease of flux only with mental stress. Laser Doppler flowmetry showed a reduction in conductance during both tests--this reduction was smaller with eprosartan during handgrip. None of the molecules affected the conductance during mental stress. While both were able to reduce microcirculatory decrease in conductance; in particular, eprosartan controlled this drop during handgrip better than valsartan. CONCLUSIONS: Angiotensin II receptor type 1 inhibition exerts protective effects during adrenergic and noradrenergic stress in hypertensives. Eprosartan is more efficacious than valsartan in controlling noradrenergic effects.
Authors:
Enrico Arosio; Sergio De Marchi; Manlio Prior; Anna Rigoni; Alessandro Lechi
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension     Volume:  23     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-08     Completed Date:  2005-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1923-7     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Rehabilitation, University of Verona, Valeggio sul Mincio, Italy. riabvasc@mail.univr.it
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MeSH Terms
Descriptor/Qualifier:
Acrylates / administration & dosage,  therapeutic use*
Angiotensin II Type 1 Receptor Blockers / administration & dosage,  therapeutic use
Antihypertensive Agents / administration & dosage,  therapeutic use
Blood Pressure / drug effects
Female
Forearm / blood supply
Hand Strength / physiology
Heart Rate / drug effects
Humans
Hypertension / drug therapy*,  physiopathology
Imidazoles / administration & dosage,  therapeutic use*
Laser-Doppler Flowmetry
Male
Microcirculation / drug effects
Middle Aged
Skin / blood supply
Stress, Psychological / physiopathology
Tetrazoles / administration & dosage,  therapeutic use*
Thiophenes / administration & dosage,  therapeutic use*
Time Factors
Treatment Outcome
Valine / administration & dosage,  analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Acrylates; 0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Imidazoles; 0/Tetrazoles; 0/Thiophenes; 133040-01-4/eprosartan; 137862-53-4/valsartan; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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