Document Detail

Haemodynamic effects of dobutamine in patients with coronary artery disease.
MedLine Citation:
PMID:  838109     Owner:  NLM     Status:  MEDLINE    
The haemodynamic effects of the infusion of dobutamine in dosages of 2-5, 5-0 and 10-0 mug/kg/min were studied in twelve patients with coronary artery disease. At the lowest dose, infusion of dobutamine caused a significant increase in cardiac output; greater increases occurred with doses of 5-0 and 10-0 mug/kg/min. The means by which the myocardium produced the increase in cardiac output differed according to the dose of the drug; 2-5 and 5-0 mug/kg/min produced an increase in stroke volume without any significant variation in the heart rate. At the highest dose rate, an increase in heart rate made a distinct contribution to the overall increase in output. The ventricular dp/dt max. increased at all three dosages. Blood pressure, pulmonary arterial and capillary pressure, and left ventricular and diastolic pressure did not show any significant change. The separation of the inotropic and the chronotropic effects of dobutamine according to the infused dose appears to have extremely interesting clinical implications.
B Magnani; E Ambrosioni; A Branzi; F Picchio; P Capitanucci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  5     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  1977  
Date Detail:
Created Date:  1977-04-15     Completed Date:  1977-04-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  10-7     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Catecholamines / pharmacology*
Coronary Disease / drug therapy*
Dobutamine / pharmacology*,  therapeutic use
Dose-Response Relationship, Drug
Heart Failure / drug therapy
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Vascular Resistance / drug effects
Reg. No./Substance:
0/Catecholamines; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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