Document Detail


Haemodynamic effects of bopindolol and atenolol in coronary artery disease. A noninvasive study.
MedLine Citation:
PMID:  2248757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bopindolol, a new non-selective betablocker, and atenolol, a conventional betablocker, were studied in parallel groups of eight normotensive patients with NYHA II-III angina pectoris. Non-invasive haemodynamic measurements were made using echocardiography and systolic time intervals. Drug doses were 1 mg bopindolol and 100 mg atenolol once daily; measurements were made immediately and at one and six weeks intervals. Both drugs reduced heart rate, atenolol from 62 to 47 beats/minute (24%, P less than 0.01) and bopindolol from 64 to 56 beats/minute (13%, P less than 0.05) at 24 hours. Only atenolol reduced mean blood pressure. Rate pressure product was persistently reduced by atenolol (30% at 24 hours), while with bopindolol this effect lessened with time. Opposite trends in left ventricular enddiastolic and endsystolic diameters were observed; with atenolol tending to increase and bopindolol to lower them. Atenolol had no influence on cardiac contractility, while bopindolol increased it, which was shown by enhancements in the fractional shortening, ejection fraction and maximum velocity of fibre shortening. Neither drug changed peripheral vascular resistance or systolic time intervals. Two patients on bopindolol left the study because of worsening symptoms of coronary artery disease, and two on atenolol owing to side effects, bradycardia and syncope in one and diarrhea in the other. In conclusion, bopindolol showed less beta-blocking effect than atenolol and it had a positive inotropic effect. Its benefit in treating coronary artery disease remains to be proved.
Authors:
J M Rapola; T J Pellinen; L Toivonen; M S Nieminen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of medicine     Volume:  22     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  1990  
Date Detail:
Created Date:  1991-01-16     Completed Date:  1991-01-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  221-4     Citation Subset:  IM    
Affiliation:
First Department of Medicine, Helsinki University Central Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Atenolol / therapeutic use*
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Disease / drug therapy*,  physiopathology,  ultrasonography
Double-Blind Method
Echocardiography
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Pindolol / analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
13523-86-9/Pindolol; 29122-68-7/Atenolol; 69010-88-4/bopindolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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