Document Detail

Haemodynamic effects of beta-adrenorecptor blockers in hypertension.
MedLine Citation:
PMID:  6245     Owner:  NLM     Status:  MEDLINE    
The haemodynamic effect pattern of beta-blockers in hypertension is discussed. The time curve of the antihypertensive effect differs from that of cardiac beta-blockade. The antihypertensive effect is characterized by a slower onset at the start of treatment and a more gradual disappearance when therapy is withdrawn. It appears that the crucial effect of beta-blockers in hypertension is a gradually developing reduction in total peripheral vascular resistance. The mechanism of this apparent vasodilator action is unknown. Various possible factors involved are mentioned. One is a reduced efficiency of transmitter release from the peripheral adrenergic neuron. Such an action may contribute to the antihypertensive effect, as judged by results of animal experiments described.
B Ablad; B Ljung; R Sannerstedt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs     Volume:  11 SUPPL 1     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1976  
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*,  therapeutic use
Heart / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy,  physiopathology*
Sympathetic Nervous System / drug effects
Synaptic Transmission / drug effects
Time Factors
Vascular Resistance / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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