| Haemodynamic effects of altering arterial oxygen saturation in preterm infants with respiratory failure. | |
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MedLine Citation:
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PMID: 10325781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To examine the haemodynamic effects of brief alteration in arterial oxygenation in preterm infants with respiratory failure. METHODS: Eighteen preterm infants with respiratory failure, aged 9-76 hours, underwent detailed Doppler echocardiographic assessment at 86%, 96%, and 100% SaO2, achieved by altering the FIO2. Sixteen were receiving intermittent positive pressure ventilation, median FIO2 0.45 (0.20-0.65), median mean airway pressure 12 cm H2O (0-20). SaO2 was stable for 15 minutes at each stage. Four parameters of pulmonary arterial pressure were measured: peak velocity of tricuspid regurgitation and peak velocity of left to right ductal flow, TPV:RVET ratio and PEP:RVET ratio, measured at the pulmonary valve, along with flow velocity integrals at the aortic and pulmonary valves, and systemic arterial pressure. Ductal size was graded into closed, small, moderate, large with imaging, pulsed and continuous wave Doppler. RESULTS: Between 86% and 96% SaO2, there were no consistent changes, but in three of the 12 with a patent ductus arteriosus (PDA) there was ductal constriction, with complete closure in one. Between 96% and 100% SaO2, peak ductal flow velocity rose significantly in four of eight with a PDA. Ductal constriction occurred in four infants; in three this was associated with a significant fall in aortic flow integral and a rise in aortic pressure (4-6 mm Hg). Overall, 11 infants went from 86% to 100% SaO2 and pulmonary arterial pressure fell significantly in seven. CONCLUSION: A brief rise in SaO2 within the range maintained by most neonatal units can cause significant ductal constriction. The fall in pulmonary arterial pressure with 100% SaO2 seen in most infants was associated with a fall in pulmonary blood flow (or no change), rather than a rise, indicating that the dominant haemodynamic effect was ductal constriction rather than pulmonary vasodilation. |
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Authors:
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J R Skinner; S Hunter; C F Poets; D W Milligan; D Southall; E N Hey |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 80 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: ENGLAND |
Other Details:
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Languages: eng Pagination: F81-7 Citation Subset: AIM; IM |
Affiliation:
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Department Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne. JSkinner@AHSL.co.nz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Confidence Intervals Ductus Arteriosus, Patent / blood*, physiopathology, therapy Echocardiography, Doppler Hemodynamics* Humans Hyaline Membrane Disease / blood*, physiopathology, therapy Infant, Newborn Infant, Premature / blood Intermittent Positive-Pressure Ventilation Oxygen / blood* Pulmonary Artery Pulmonary Wedge Pressure Regional Blood Flow |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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