| Haemodynamic effects of acute intravenous metoprolol in apical ballooning syndrome with dynamic left ventricular outflow tract obstruction. | |
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MedLine Citation:
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PMID: 20097684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Takotsubo syndrome, also called apical ballooning syndrome, is a clinical entity characterized by transient hypokinesis, akinesis, or dyskinesis of the left ventricular mid-segments with or without apical involvement, and without obstructive coronary lesions. The contemporary presence of left ventricular outflow tract obstruction (LVOTO), systolic anterior motion of the anterior mitral leaflet, and acute mitral regurgitation might explain the worsening of the heart failure or the occurrence of cardiogenic shock in some patients with apical ballooning syndrome. The use of beta-blockers should improve the LVOTO gradient by reducing basal hypercontractility, increasing left ventricular filling and size, and reducing heart rate. However, clear evidence of the direct haemodynamic effects of beta-blockers is still lacking. We present a case of apical ballooning syndrome complicated by dynamic LVOTO, treated with metoprolol. |
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Authors:
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Federico Migliore; Claudio Bilato; Gianbattista Isabella; Sabino Iliceto; Giuseppe Tarantini |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-01-22 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-16 Completed Date: 2010-06-10 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 305-8 Citation Subset: IM |
Affiliation:
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Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Policlinico Universitario, Via Giustiniani, 2, 35128 Padova, Italy. federico.migliore@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage,
therapeutic use* Angina Pectoris Female Heart Ventricles / pathology, ultrasonography Hemodynamics / drug effects* Humans Injections, Intravenous Metoprolol / administration & dosage, therapeutic use* Middle Aged Mitral Valve Insufficiency / physiopathology Takotsubo Cardiomyopathy / complications, drug therapy*, ultrasonography Ventricular Outflow Obstruction / complications, drug therapy*, physiopathology, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 37350-58-6/Metoprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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