| Haemodynamic dose-response effects of intravenous nisoldipine in coronary artery disease. | |
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MedLine Citation:
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PMID: 4091998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The circulatory consequences of slow-calcium channel blockade with a new dihydropyridine nisoldipine were evaluated at rest and during exercise-induced angina in 16 patients with angiographically proven coronary artery disease. In 10 patients resting cardiac stroke output (thermodilution) and pulmonary artery occluded pressure were determined following four intravenous nisoldipine injections (cumulative dosage of 1, 2, 4 and 8 micrograms kg-1). The exercise effects of nisoldipine were evaluated by comparing the effects of the 8 micrograms kg-1 cumulative dosage with a control exercise period at the same workload. At rest nisoldipine reduced systemic vascular resistance and mean arterial pressure, and increased heart rate, cardiac and stroke volume indices. During 4 min supine-bicycle exercise nisoldipine reduced systemic mean arterial pressure and vascular resistance; this resulted in augmented cardiac and stroke volume indices at an unchanged pulmonary artery occluded pressure. In six additional patients rest and exercise ejection fractions were measured using a nonimaging nuclear probe. Nisoldipine (4 micrograms kg-1) resulted in a small trend to increase left ventricular rest and exercise ejection fraction. These data demonstrated improved rest and exercise cardiac performance following nisoldipine in patients with severe coronary artery disease. |
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Authors:
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B Silke; M A Frais; P Muller; S P Verma; G Reynolds; S H Taylor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 20 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-04-04 Completed Date: 1986-04-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 675-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Calcium Channel Blockers / therapeutic use* Cardiac Output / drug effects Coronary Disease / drug therapy*, physiopathology Dose-Response Relationship, Drug Exercise Test Female Hemodynamics / drug effects* Humans Male Middle Aged Nifedipine / analogs & derivatives*, therapeutic use Nisoldipine Oxygen Consumption / drug effects Pulmonary Circulation / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 63675-72-9/Nisoldipine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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