Document Detail

Haemodynamic and blood gas changes in buffaloes (Bubalus bubalis) in the supine position following thiopentone anaesthesia with premedication.
MedLine Citation:
PMID:  3576966     Owner:  NLM     Status:  MEDLINE    
Studies were undertaken on seven adult female buffaloes (Bubalus bubalis) premedicated with triflupromazine hydrochloride (0.3 mg/kg) and chloral hydrate (30 mg/kg). Anaesthesia was induced with thiopentone sodium (10 mg/kg) and animals were kept under intermittent positive pressure ventilation. Measurements were made for 30 min in the lateral position, for 20 min in the supine position and subsequently for 40 min again in the lateral position. Regurgitation during anaesthesia was avoided by evacuation of the rumen by rumenotomy two days prior to the experiment. When animals were in the lateral position there were minimal changes in arterial pressure and heart rate but central venous pressure rose. These changes were related to intermittent positive pressure ventilation. In the supine position, increase in heart rate (28%) was associated with profound hypotension (56%) and decrease in central venous pressure (171%) in these animals. There was a fall in venous oxygen tension and a marked increase (91%) in oxygen extraction ratio. Restoration to the lateral position ameliorated all these changes rapidly. It was suggested that a 'low pressure-low flow' circulatory state exists in anaesthetised adult buffaloes in the supine position.
P K Peshin; D Krishnamurthy; K Singh; M N Nassimi; J M Nigam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary research communications     Volume:  11     ISSN:  0165-7380     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  1987  
Date Detail:
Created Date:  1987-06-16     Completed Date:  1987-06-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Anesthesia / veterinary*
Buffaloes / physiology*
Chloral Hydrate / pharmacology
Hemodynamics* / drug effects
Oxygen / blood*
Premedication / veterinary
Thiopental / pharmacology*
Triflupromazine / pharmacology
Reg. No./Substance:
146-54-3/Triflupromazine; 302-17-0/Chloral Hydrate; 76-75-5/Thiopental; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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