| Haemodilution tolerance in patients with mitral regurgitation. | |
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MedLine Citation:
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PMID: 9505737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Haemodynamic parameters and oxygen consumption were determined in 20 patients with mitral regurgitation before and after a 12 ml.kg-1 isovolaemic exchange of blood for 6% hydroxyethyl starch. During haemodilution, mean (SEM) haemoglobin concentration decreased from 13.0 (0.4) to 10.3 (0.4) g.dl-1 (p = 0.001). With cardiac filling pressures maintained at predilution levels, cardiac index increased from 1.84 (0.08) to 1.94 (0.08) l.min-1.m-2 (p = 0.025) while systemic vascular resistance decreased from 1556 (86) to 1425 (83) dyne.s.cm-5 (p = 0.002) and oxygen extraction increased from 31.7 (1.1) to 37.3 (1.4)% (p = 0.001) resulting in an unchanged oxygen consumption. The haemodynamic response to haemodilution was not affected by the patients' cardiac rhythm, i.e. whether it was sinus rhythm or atrial fibrillation. In conclusion, isovolaemic haemodilution to a haemoglobin of 10.3 g.dl-1 is well tolerated in patients with mitral regurgitation. Compensatory mechanisms include both an increase in cardiac index and an increase in oxygen extraction. |
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Authors:
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D R Spahn; B Seifert; T Pasch; E R Schmid |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Anaesthesia Volume: 53 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-03-25 Completed Date: 1998-03-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 20-4 Citation Subset: AIM; IM |
Affiliation:
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Institute of Anaesthesiology, University Hospital, University of Zürich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrial Fibrillation / physiopathology Cardiac Output Female Hemodilution* Hemoglobins / metabolism Hetastarch Humans Intraoperative Care Male Middle Aged Mitral Valve Insufficiency / blood, physiopathology*, surgery* Oxygen Consumption Plasma Substitutes Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Plasma Substitutes; 9005-27-0/Hetastarch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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