Document Detail

Haemodialysis-induced leucopenia and activation of complement: effects of different membranes.
MedLine Citation:
PMID:  740661     Owner:  NLM     Status:  MEDLINE    
The effects on neutrophil count and complement activity of five different haemodialysis membranes were studied. There was no correlation between the degree of neutropenia and intensity of complement activation. With cuprophan membrane both occurred simultaneously but to unrelated degrees; polyacronitrile induced mild, not significant neutropenia but marked activation of complement; polycarbonate membranes induced severe neutropenia without detectable complement activation. Where complement activation occurred it was via the alternative pathway. Haemodialysis induced neutropenia may have many causes and complement activation is probably not the major responsible factor.
P Aljama; P A Bird; M K Ward; T G Feest; W Walker; H Tanboga; M Sussman; D N Kerr
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  15     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1978  
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  144-53     Citation Subset:  IM    
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MeSH Terms
Acrylic Resins
Cellulose / analogs & derivatives
Complement Activation*
Complement Pathway, Alternative
Kidney, Artificial / instrumentation*
Leukopenia / etiology*
Membranes, Artificial*
Neutropenia / etiology
Renal Dialysis / adverse effects*
Reg. No./Substance:
0/Acrylic Resins; 0/Carbonates; 0/Membranes, Artificial; 0/Polymers; 107-13-1/Acrylonitrile; 7440-50-8/Copper; 9004-34-6/Cellulose

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