Document Detail


Haemoconcentration, shear-stress increase and carotid artery diameter regulation after furosemide administration in older hypertensives.
MedLine Citation:
PMID:  11250127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to determine whether changes of carotid wall shear stress induced by changes in blood viscosity after diuretic administration cause carotid arterial dilatation in elderly hypertensives, as reported in the cat. Arterial wall shear rate (ultrasound technique, profilmeter FRP III), the systo-diastolic diameter (echotracking technique) and the mean blood flow velocity and volume of the common carotid artery, the blood viscosity (rotational viscometer) and the finger arterial blood pressure (Finapress Ohmeda) were measured in 12 young volunteers (aged 25+/-2 years) and in 12 elderly hypertensives (aged 80+/-4 years) treated with short-acting calcium antagonists up to 24h before the study, both at baseline and after intravenous furosemide infusion (0.5mg/min), when the haematocrit had increased by at least two percentage points. After furosemide administration the mean arterial blood pressure decreased and blood viscosity and carotid systolic shear stress increased in both groups. However, common carotid artery diameter increased only in the young controls but not in the elderly hypertensives. These data show that an increase in carotid shear stress caused by haemoconcentration induces carotid vasodilatation only in young healthy subjects, and not in elderly hypertensives. This effect may be related to impaired endothelium function and/or arterial wall mechanics.
Authors:
M Fazio; M Bardelli; F Cominotto; F Fiammengo; B Fabris; F Fischetti; R Candido; L Pascazio; R Lapasin; R Carretta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental gerontology     Volume:  36     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-16     Completed Date:  2001-05-21     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  571-81     Citation Subset:  IM    
Affiliation:
Department of Clinical Medicine, c/o Ospedale di Cattinara, U.C.O. di Medicina Clinica, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aging
Animals
Blood Pressure / drug effects
Blood Viscosity / drug effects
Carotid Artery, Common / drug effects,  physiology,  physiopathology*
Cats
Diuretics / pharmacology
Female
Furosemide / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hypertension / blood,  physiopathology*
Male
Stress, Mechanical
Vasodilation / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Diuretics; 54-31-9/Furosemide

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