Document Detail


Haemochromatosis genotype and iron overload: association with hypertension and left ventricular hypertrophy.
MedLine Citation:
PMID:  20337854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We hypothesized that there is an association between haemochromatosis genotype C282Y/C282Y and/or iron overload and risk of hypertension and/or left ventricular hypertrophy (LVH). METHODS: We analysed data from a cross-sectional study of the general population including 8992 individuals from the Copenhagen City Heart Study (CCHS), a follow-up study of 36,480 individuals from the Copenhagen General Population Study (CGPS), and a case-only study of 3815 Scandinavians from the Losartan Intervention For End-point Reduction in Hypertension Genetic Substudy (LIFEGEN) with LVH and hypertension. RESULTS: In the CCHS, individuals with C282Y/C282Y versus wild type/wild type had an odds ratio for antihypertensive medication use of 4.8 (1.8-13; P = 0.003). In the CGPS, the corresponding hazard ratio was 1.7 (1.0-2.3; P = 0.003). Also, hazard ratios for antihypertensive medication use in the CGPS were 1.6 (1.0-2.6; P = 0.05) for transferrin saturation > or =80% vs. <50%, and 2.3 (1.3-4.2; P = 0.005) for C282Y/C282Y + transferrin saturation > or =80% vs. wild type/wild type + transferrin saturation <50%. These results were most pronounced in men above 55 years of age. We did not find any association between C282Y/C282Y or iron overload and LVH or hypertension (measured as blood pressure at a single occasion or continuous blood pressure), or LVH with hypertension in the CCHS or with severity of LVH in LIFEGEN. CONCLUSIONS: We found that haemochromatosis genotype C282Y/C282Y and extremely elevated transferrin saturation either separately or combined were associated with increased risk of antihypertensive medication use. Therefore, testing for haemochromatosis genotype C282Y/C282Y and extreme transferrin saturation could be considered in patients with essential hypertension.
Authors:
C Ellervik; A Tybjaerg-Hansen; M Appleyard; H Ibsen; B G Nordestgaard
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-01-29
Journal Detail:
Title:  Journal of internal medicine     Volume:  268     ISSN:  1365-2796     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  252-64     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Antihypertensive Agents / administration & dosage
Cross-Sectional Studies
Drug Administration Schedule
Drug Utilization / statistics & numerical data
Female
Follow-Up Studies
Genotype
Hemochromatosis / blood,  complications*,  genetics
Humans
Hypertension / etiology*,  genetics
Hypertrophy, Left Ventricular / etiology*,  genetics
Iron Overload / complications*,  genetics
Male
Middle Aged
Transferrin / analysis
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 11096-37-0/Transferrin
Comments/Corrections
Comment In:
J Intern Med. 2010 Sep;268(3):246-8   [PMID:  20695974 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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