Document Detail

Haematopoietic progenitors in essential thrombocythaemia.
MedLine Citation:
PMID:  6836227     Owner:  NLM     Status:  MEDLINE    
Colony formation by haematopoietic progenitors from the bone marrow and blood of 4 patients with essential thrombocythaemia was studied in vitro using the methyl cellulose assay. 3 patients had clearly elevated numbers of BFU-E in bone marrow. 1 patient also had markedly increased numbers of CFU-E and CFU-GM, whereas the other patients had only marginally increased or normal numbers of these progenitors in the marrow. 3 patients showed markedly increased numbers of all progenitors in peripheral blood. All 4 patients showed spontaneous erythroid colony formation by progenitors from the bone marrow and 2 had spontaneous colony formation by progenitors from the blood. We conclude that essential thrombocythaemia shows abnormal colony formation in line with other myeloproliferative syndromes.
S Partanen; T Ruutu; P Vuopio
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of haematology     Volume:  30     ISSN:  0036-553X     ISO Abbreviation:  Scand J Haematol     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404507     Medline TA:  Scand J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  130-4     Citation Subset:  IM    
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MeSH Terms
Bone Marrow Cells
Colony-Forming Units Assay*
Erythrocytes / cytology
Granulocytes / cytology
Hematopoietic Stem Cells / cytology*
Middle Aged
Monocytes / cytology
Thrombocytosis / blood*

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