Document Detail


Haematological malignancies--a predictor of a poor outcome in patients with bacteraemia.
MedLine Citation:
PMID:  16352338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To compare microbial agents causing first episodes of bacteraemia in patients with and without haematological malignancies, and to examine mortality within 90 days of follow-up. METHODS: We conducted a population-based study in North Jutland County, Denmark including patients (> or = 15 years) registered in the County Bacteraemia Registry with their first episode of bacteraemia during the period 1992-2002. Diseases prior to the bacteraemia were identified in the Hospital Discharge Registry. Mortality was determined through the Civil Registration System. We estimated adjusted mortality rate ratios (MRRs) using Cox's regression analysis. RESULTS: We included 7456 patients with a first episode of bacteraemia; of these, 444 (6%) had a haematological malignancy. Haematological patients had almost the same proportions of gram-negative (49% vs. 50%) and gram-positive (37% vs. 39%) bacteraemia as other patients. Cumulative 30-day mortality in patients with haematological malignancies was 32% vs. 20% in patients without any malignancy, yielding an adjusted MRR of 1.6 (95% CI 1.3-2.0). For patients with non-haematological malignancies the adjusted MRR was 1.5 (95% CI 1.4-1.7). CONCLUSION: Despite a similar distribution of the microbial agents causing bacteraemia, patients with haematological malignancies and also patients with non-haematological malignancies had increased 30-day mortality of bacteraemia when compared with patients without any malignancy.
Authors:
Mette Nørgaard; Heidi Larsson; Gitte Pedersen; Henrik Carl Schønheyder; Henrik Toft Sørensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-13
Journal Detail:
Title:  The Journal of infection     Volume:  53     ISSN:  1532-2742     ISO Abbreviation:  J. Infect.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2006-10-24     Revised Date:  2007-12-14    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  190-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, DK-8000 Aarhus C, Denmark. aas.uxmeno@nja.dk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Bacteremia / complications*,  microbiology,  mortality*
Denmark / epidemiology
Female
Gram-Negative Bacteria
Gram-Positive Bacteria
Hematologic Neoplasms / complications*,  mortality
Humans
Male
Middle Aged
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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