Document Detail

Haematological cancers in pregnancy.
MedLine Citation:
PMID:  22325663     Owner:  NLM     Status:  MEDLINE    
Haematological cancer in pregnancy, although rare, poses a substantial risk to both mother and fetus. Hodgkin's lymphoma is the most common, followed by non-Hodgkin lymphoma and acute leukaemia. Diagnosis of haematological cancers is challenged by an overlap of the disease and gestation-related symptoms and limitations of imaging studies in pregnancy. Data for safety and effectiveness of therapy are scarce and mostly retrospective. This report provides updated guidance for management, focusing on chemotherapy and biological agents. The primary goal of treatment is to preserve the mother's health; hence, pregnancy termination is often advisable at early stages, allowing delivery of adequate therapy. However, at later gestational stages treatment is often feasible. Pregnancy-related hypercoagulability, augmented by cancer, often necessitates thromboprophylaxis. The consequences and complex management of haematological cancer during pregnancy emphasise the need for collaborative research, focusing on basic mechanisms of disease and prospective epidemiological studies.
Benjamin Brenner; Irit Avivi; Michael Lishner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lancet     Volume:  379     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-02-21     Revised Date:  2012-05-29    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  580-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
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MeSH Terms
Hematologic Neoplasms / diagnosis,  therapy*
Leukemia / diagnosis,  therapy
Lymphoma / diagnosis,  therapy
Multiple Myeloma / diagnosis,  therapy
Pregnancy Complications, Hematologic / prevention & control
Pregnancy Complications, Neoplastic / diagnosis,  therapy*
Thrombosis / prevention & control
Comment In:
Lancet. 2012 May 26;379(9830):1948; author reply 1949   [PMID:  22633029 ]

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