| Haematologic parameters and pregnancy outcome. A prospective cohort study in the third trimester. | |
| | |
MedLine Citation:
|
PMID: 2324786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The relationship between haematologic parameters and pregnancy outcome was investigated in a prospective study, taking important covariates into consideration. A questionnaire asking information about smoking, alcohol consumption and iron intake was completed by a consecutive series of 796 ambulatory singleton pregnant women at 31-32 weeks of gestation. Subsequently, haematologic parameters were measured. After delivery, birth weight, gestation length and blood pressure values during pregnancy were abstracted from the obstetricians' records. Low birth weight (less than 2.500 g) and preterm birth (less than 37 weeks), were significantly more frequently seen in women with high haemoglobin (greater than or equal to 8.0 mmol/l) or high haematocrit (greater than 38%) values, with Mantel-Haenszel odds ratios varying from 2.4 to 4.2. Also a high erythrocyte count (greater than or equal to 4.5/pl) was correlated with low birth weight, while for mean corpuscular volume (MCV) no such relationships were found. Pregnancy induced hypertension was positively associated with haemoglobin, haematocrit and erythrocyte count, but could not fully explain the relationships between these parameters and adverse outcomes. Using multiple logistic regression with low birth weight and or preterm birth as the dependent variable, the effect of haematocrit still was demonstrable after controlling for smoking, hypertension, parity, alcohol consumption and iron intake. These results are in agreement with the hypothesis that a higher blood viscosity is a risk factor for suboptimal placenta-perfusion. |
| | |
Authors:
|
J A Knottnerus; L R Delgado; P G Knipschild; G G Essed; F Smits |
Related Documents
:
|
14517546 - Pregnancy weight gain from 1960s to 2000 in finland. 12846366 - Associations of maternal and umbilical cord hormone concentrations with maternal, gesta... 2748356 - The relationship between weight gain and nutrition in pregnancy. 16431676 - The effect of parity on placental weight and birth weight: interaction with placental a... 615456 - Determination of l-lactate: nad+ - oxidoreductase (e.c.1.1.1.27) and its isoenzymes dur... 18807606 - Spontaneous hepatic rupture during third trimester of pregnancy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical epidemiology Volume: 43 ISSN: 0895-4356 ISO Abbreviation: J Clin Epidemiol Publication Date: 1990 |
Date Detail:
|
Created Date: 1990-05-24 Completed Date: 1990-05-24 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8801383 Medline TA: J Clin Epidemiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 461-6 Citation Subset: IM |
Affiliation:
|
Department of General Practice, University of Limburg, Maastricht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alcohol Drinking Cohort Studies Erythrocyte Count Erythrocyte Indices Female Hematocrit Hemoglobins / analysis Humans Hypertension / complications Iron / therapeutic use Parity Pregnancy / blood* Pregnancy Complications Pregnancy Outcome* / epidemiology Pregnancy Trimester, Third Prospective Studies Smoking |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thyroid nodularity after childhood irradiation for lymphoid hyperplasia: a comparison of questionnai...
Next Document: The WHO principles for registering causes of death: suggestions for improvement.