Document Detail

Haematologic parameters and pregnancy outcome. A prospective cohort study in the third trimester.
MedLine Citation:
PMID:  2324786     Owner:  NLM     Status:  MEDLINE    
The relationship between haematologic parameters and pregnancy outcome was investigated in a prospective study, taking important covariates into consideration. A questionnaire asking information about smoking, alcohol consumption and iron intake was completed by a consecutive series of 796 ambulatory singleton pregnant women at 31-32 weeks of gestation. Subsequently, haematologic parameters were measured. After delivery, birth weight, gestation length and blood pressure values during pregnancy were abstracted from the obstetricians' records. Low birth weight (less than 2.500 g) and preterm birth (less than 37 weeks), were significantly more frequently seen in women with high haemoglobin (greater than or equal to 8.0 mmol/l) or high haematocrit (greater than 38%) values, with Mantel-Haenszel odds ratios varying from 2.4 to 4.2. Also a high erythrocyte count (greater than or equal to 4.5/pl) was correlated with low birth weight, while for mean corpuscular volume (MCV) no such relationships were found. Pregnancy induced hypertension was positively associated with haemoglobin, haematocrit and erythrocyte count, but could not fully explain the relationships between these parameters and adverse outcomes. Using multiple logistic regression with low birth weight and or preterm birth as the dependent variable, the effect of haematocrit still was demonstrable after controlling for smoking, hypertension, parity, alcohol consumption and iron intake. These results are in agreement with the hypothesis that a higher blood viscosity is a risk factor for suboptimal placenta-perfusion.
J A Knottnerus; L R Delgado; P G Knipschild; G G Essed; F Smits
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical epidemiology     Volume:  43     ISSN:  0895-4356     ISO Abbreviation:  J Clin Epidemiol     Publication Date:  1990  
Date Detail:
Created Date:  1990-05-24     Completed Date:  1990-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8801383     Medline TA:  J Clin Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  461-6     Citation Subset:  IM    
Department of General Practice, University of Limburg, Maastricht, The Netherlands.
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MeSH Terms
Alcohol Drinking
Cohort Studies
Erythrocyte Count
Erythrocyte Indices
Hemoglobins / analysis
Hypertension / complications
Iron / therapeutic use
Pregnancy / blood*
Pregnancy Complications
Pregnancy Outcome* / epidemiology
Pregnancy Trimester, Third
Prospective Studies
Reg. No./Substance:
0/Hemoglobins; 7439-89-6/Iron

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