| Habitual exercise enhances neuromuscular transmission efficacy of rat soleus muscle in situ. | |
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MedLine Citation:
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PMID: 11181618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat motor nerve terminals and the endplates they interact with exhibit changes to varying patterns of use, as when exposed to increased activation in the form of endurance exercise training. The extent to which these changes affect neuromuscular transmission efficacy is uncertain. In this study, the effects of habitual exercise on the electrophysiological properties of neuromuscular transmission in rat soleus muscle were investigated using a novel in situ approach. Consistent with previous reports, miniature endplate potential frequency was enhanced by habitual exercise. Other passive properties, such as resting membrane potential, miniature endplate potential amplitude, and "giant" miniature endplate potential characteristics were unaltered by the training program. Full-size endplate potentials were obtained by blocking soleus muscle action potentials with mu-conotoxin GIIIb. Quantal content values were 91.5 and 119.9 for control and active groups, respectively (P < 0.01). We also measured the rate and extent of endplate potential amplitude rundown during 3-s trains of continuous stimulation at 25, 50, and 75 Hz; at 50 and 75 Hz, we found both the rate and extent of rundown to be significantly attenuated (10--20%) in a specific population of cells from active rats (P < 0.05). The results establish the degree of activity-dependent plasticity as it pertains to neuromuscular transmission in a mammalian slow-twitch muscle. |
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Authors:
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P Desaulniers; P A Lavoie; P F Gardiner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 90 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-05-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1041-8 Citation Subset: IM; S |
Affiliation:
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Département de Kinésiologie, Université de Montréal, Montréal, Québec, Canada H3C 3J7. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Conotoxins / pharmacology Electric Stimulation Female Hindlimb Membrane Potentials / physiology Motor Endplate / physiology Muscle, Skeletal / innervation, physiology* Neuromuscular Junction / physiology* Physical Conditioning, Animal / physiology* Physical Exertion / physiology Rats Rats, Sprague-Dawley Sodium Channels / drug effects Synaptic Transmission / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Conotoxins; 0/Sodium Channels; 101484-15-5/conotoxin GIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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