| Habitual dietary sodium intake is inversely associated with coronary flow reserve in middle-aged male twins. | |
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MedLine Citation:
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PMID: 22258268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Evidence links dietary sodium to hypertension and cardiovascular disease (CVD), but investigation of its influence on cardiovascular function is limited. OBJECTIVE: We examined the relation between habitual dietary sodium and coronary flow reserve (CFR), which is a measure of overall coronary vasodilator capacity and microvascular function. We hypothesized that increased sodium consumption is associated with lower CFR. DESIGN: Habitual daily sodium intake for the previous 12 mo was measured in 286 male middle-aged twins (133 monozygotic and dizygotic pairs and 20 unpaired twins) by using the Willett food-frequency questionnaire. CFR was measured by positron emission tomography [N(13)]-ammonia, with quantitation of myocardial blood flow at rest and after adenosine stress. Mixed-effects regression analysis was used to assess the association between dietary sodium and CFR. RESULTS: An increase in dietary sodium of 1000 mg/d was associated with a 10.0% lower CFR (95% CI: -17.0%, -2.5%) after adjustment for demographic, lifestyle, nutritional, and CVD risk factors (P = 0.01). Across quintiles of sodium consumption, dietary sodium was inversely associated with CFR (P-trend = 0.03), with the top quintile (>1456 mg/d) having a 20% lower CFR than the bottom quintile (<732 mg /d). This association also persisted within pairs: a 1000-mg/d difference in dietary sodium between brothers was associated with a 10.3% difference in CFR after adjustment for potential confounders (P = 0.02). CONCLUSIONS: Habitual dietary sodium is inversely associated with CFR independent of CVD risk factors and shared familial and genetic factors. Our study suggests a potential novel mechanism for the adverse effects of dietary sodium on the cardiovascular system. This trial was registered at clinicaltrials.gov as NCT00017836. |
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Authors:
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Silvia C Eufinger; John Votaw; Tracy Faber; Thomas R Ziegler; Jack Goldberg; J Douglas Bremner; Viola Vaccarino |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Twin Study Date: 2012-01-18 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 95 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-21 Completed Date: 2012-04-09 Revised Date: 2012-04-23 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 572-9 Citation Subset: AIM; IM |
Affiliation:
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Nutrition and Health Sciences Program, Emory University, Atlanta, GA 30322, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00017836 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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metabolism Cardiovascular Diseases / physiopathology, prevention & control Food Habits* Fractional Flow Reserve, Myocardial / drug effects* Humans Hypertension / physiopathology, prevention & control Life Style Linear Models Male Middle Aged Nutrition Assessment Positron-Emission Tomography / methods Questionnaires Risk Factors Sodium, Dietary / administration & dosage*, adverse effects* Twins |
| Grant Support | |
ID/Acronym/Agency:
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F31 HL107080/HL/NHLBI NIH HHS; F31HL107080/HL/NHLBI NIH HHS; K24 HL077506/HL/NHLBI NIH HHS; K24 MH076955/MH/NIMH NIH HHS; K24 RR023356/RR/NCRR NIH HHS; M01-RR00039/RR/NCRR NIH HHS; R01 AG026255/AG/NIA NIH HHS; R01 HL68630/HL/NHLBI NIH HHS; T32 MH067547/MH/NIMH NIH HHS; UL1 RR025008/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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