| HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance. | |
| | |
MedLine Citation:
|
PMID: 21679708 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
HVEM is a member of the TNF receptor superfamily that plays a role in the development of various inflammatory diseases. In this study, we show that HVEM deficiency attenuates adipose tissue inflammatory responses and glucose intolerance in diet-induced obesity. Feeding a high-fat diet (HFD) to HVEM-deficient mice elicited a reduction in the number of macrophages and T cells infiltrated into adipose tissue. Proinflammatory cytokine levels in the adipose tissue decreased in HFD-fed HVEM-deficient mice, while levels of the anti-inflammatory cytokine IL-10 increased. Moreover, glucose intolerance and insulin sensitivity were markedly improved in the HFD-fed HVEM-deficient mice. These findings indicate that HVEM may be a useful target for combating obesity-induced inflammatory responses and insulin resistance. |
| | |
Authors:
|
Ha-Jung Kim; Hong-Min Kim; Chu-Sook Kim; Choon-Soo Jeong; Hye-Sun Choi; Teruo Kawada; Byung-Sam Kim; Rina Yu |
Related Documents
:
|
8242008 - Physiological effects of weight cycling in female lightweight rowers. 15632788 - Patterns of weight and body composition change in premenopausal women with early stage ... 4066538 - Developmental comparisons of boars and barrows: ii. body composition and bone development. 3351978 - Body and organ weights of rats exposed to carbon monoxide at high altitude. 10519718 - Effect of an individualised training programme during weight reduction on body composit... 16897538 - Development of a grassland integrity index based on breeding bird assemblages. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-13 |
Journal Detail:
|
Title: FEBS letters Volume: - ISSN: 1873-3468 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
|
Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carbohydrate and amino acid metabolism of Spironucleus vortens.
Next Document: Distal esophageal spasm in high-resolution esophageal pressure topography: defining clinical phenoty...